D
David E. Kleiner
Researcher at National Institutes of Health
Publications - 560
Citations - 60934
David E. Kleiner is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Liver biopsy & Medicine. The author has an hindex of 104, co-authored 495 publications receiving 50296 citations. Previous affiliations of David E. Kleiner include University of Virginia & Tufts University.
Papers
More filters
Journal ArticleDOI
Expanding the phenotype of COPA syndrome: a kindred with typical and atypical features.
Angelo M. Taveira-DaSilva,Thomas C. Markello,David E. Kleiner,Amanda M. Jones,Catherine Groden,Ellen Macnamara,Tadafumi Yokoyama,William A. Gahl,Bernadette R. Gochuico,Joel Moss +9 more
TL;DR: Worsening severity with successive generations may be observed in Copa syndrome, andExtrapulmonary cysts, malignancies, autoimmune neurological disorders and infections are clinical features that may be associated with CopA syndrome.
Journal ArticleDOI
Placebo in Nonalcoholic Steatohepatitis: Insight Into Natural History and Implications for Future Clinical Trials
Rohit Loomba,Rohit Loomba,Robert Wesley,Frank Pucino,T. Jake Liang,David E. Kleiner,Joel E. Lavine +6 more
TL;DR: Serum alanine aminotransferase levels may decrease on placebo and is not a reliable measure of treatment response, but a 2-point improvement in histologic parameters is rarely seen in the placebo arm and may be more reliable in assessing treatment response.
Journal ArticleDOI
Effects of Metreleptin in Pediatric Patients With Lipodystrophy.
Rebecca J. Brown,Cristina Adelia Meehan,Elaine Cochran,Kristina I. Rother,David E. Kleiner,Mary Walter,Phillip Gorden +6 more
TL;DR: Metreleptin lowered A1c and triglyceride levels, and improved biomarkers of NAFLD in pediatric patients with lipodystrophy, and these improvements are likely to reduce the lifetime burden of disease.
Journal ArticleDOI
Liver injury is associated with mortality in sickle cell disease
Jordan J. Feld,Gregory J. Kato,Christopher Koh,T. Shields,Mariana Hildesheim,David E. Kleiner,James G. Taylor,Netanya G. Sandler,Daniel C. Douek,V. Haynes-Williams,James S. Nichols,Jay H. Hoofnagle,T. Jake Liang,Mark T. Gladwin,Theo Heller +14 more
TL;DR: Increased life expectancy in sickle cell disease has resulted in greater recognition of the consequences of repeated intravascular vaso‐occlusion and chronic haemolysis to multiple organ systems.
Journal ArticleDOI
Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity.
Paul H. Hayashi,Robert J. Fontana,Naga Chalasani,Andrew Stolz,J. A. Talwalkar,Victor Navarro,William M. Lee,Timothy Davern,David E. Kleiner,Jiezhun Gu,Jay H. Hoofnagle +10 more
TL;DR: In this paper, the authors collected data on cases of isoniazid hepatotoxicity and assessed adherence to ATS guidelines and reports to the Centers for Disease Control's (CDC) severe adverse events program.