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Netanya G. Sandler
Researcher at National Institutes of Health
Publications - 27
Citations - 4530
Netanya G. Sandler is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Simian immunodeficiency virus & Cytokine. The author has an hindex of 21, co-authored 27 publications receiving 4091 citations. Previous affiliations of Netanya G. Sandler include University of Texas Medical Branch & Vaccine Research Center.
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Journal ArticleDOI
Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection
Netanya G. Sandler,Handan Wand,Annelys Roque,Matthew Law,Martha Nason,Daniel E. Nixon,Court Pedersen,Kiat Ruxrungtham,Sharon R Lewin,Sharon R Lewin,Sharon R Lewin,Sean Emery,James D. Neaton,Jason M. Brenchley,Steven G. Deeks,Irini Sereti,Daniel C. Douek +16 more
TL;DR: Therapeutic attenuation of innate immune activation may improve survival in patients with HIV infection and sCD14, a marker of monocyte response to LPS, is an independent predictor of mortality in HIV infection.
Journal ArticleDOI
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
Ivona Aksentijevich,Seth L. Masters,Polly J. Ferguson,Paul Dancey,Joost Frenkel,Annet van Royen-Kerkhoff,R. M. Laxer,Ulf Tedgård,Edward W. Cowen,Tuyet-Hang Pham,Matthew G. Booty,Jacob D. Estes,Netanya G. Sandler,Nicole Plass,Deborah L. Stone,Maria L. Turner,Suvimol Hill,John A. Butman,Rayfel Schneider,Paul Babyn,Hatem El-Shanti,Elena Pope,Karyl S. Barron,Xinyu Bing,Arian Laurence,Chyi-Chia Richard Lee,Dawn Chapelle,Gillian I. Clarke,Kamal Ohson,Marc Nicholson,Massimo Gadina,Barbara Yang,Benjamin D. Korman,Peter K. Gregersen,P. Martin van Hagen,A. Elisabeth Hak,Marjan Huizing,Proton Rahman,Daniel C. Douek,Elaine F. Remmers,Daniel L. Kastner,Raphaela Goldbach-Mansky +41 more
TL;DR: The term deficiency of the interleukin-1-receptor antagonist, or DIRA, is proposed to denote this autosomal recessive autoinflammatory disease caused by mutations affecting IL1RN, resulting in life-threatening systemic inflammation with skin and bone involvement.
Journal ArticleDOI
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression
Netanya G. Sandler,Netanya G. Sandler,Steven E. Bosinger,Jacob D. Estes,Richard T R Zhu,Gregory K. Tharp,Eli Boritz,Doron Levin,Sathi Wijeyesinghe,Krystelle Nganou Makamdop,Gregory Q. Del Prete,Brenna J. Hill,J. Katherina Timmer,Emma Reiss,Ganit Yarden,Samuel Darko,Eduardo J. Contijoch,John Paul Todd,Guido Silvestri,Martha Nason,Robert B. Norgren,Brandon F. Keele,Srinivas S. Rao,Jerome A. Langer,Jeffrey D. Lifson,Gideon Schreiber,Daniel C. Douek +26 more
TL;DR: The timing ofIFN-induced innate responses in acute SIV infection profoundly affects overall disease course and outweighs the detrimental consequences of increased immune activation, yet the clinical consequences of manipulation of IFN signalling are difficult to predict in vivo and therapeutic interventions in human studies should be approached with caution.
Journal ArticleDOI
Microbial translocation in HIV infection: causes, consequences and treatment opportunities
TL;DR: The intestinal damage that occurs in HIV infection, the evidence for translocation of microbial products into the systemic circulation and the pathways by which these products activate the immune system are described.
Journal ArticleDOI
CD4 T follicular helper cell dynamics during SIV infection
Constantinos Petrovas,Takuya Yamamoto,Michael Y. Gerner,Kristin L. Boswell,Kaska Wloka,Emily C. Smith,David R. Ambrozak,Netanya G. Sandler,J. Katherina Timmer,Xiaoyong Sun,Li Pan,Amanda C. Poholek,Srinivas S. Rao,Jason M. Brenchley,S. Munir Alam,Georgia D. Tomaras,Mario Roederer,Daniel C. Douek,Robert A. Seder,Ronald N. Germain,Elias K. Haddad,Richard A. Koup +21 more
TL;DR: Chronic SIV does not disturb the ability of TFH cells to help B cell maturation and production of SIV-specific immunoglobulins, and the phenotype, function, location, and molecular signature ofTFH cells in rhesus macaques is investigated.