David E. Kleiner

TL;DR: The many considerations inherent to planning for HSCT preceded by liver transplant in patients with primary immunodeficiencies are discussed, including the role of prolonged immunosuppression and the risk of infection prior to immune reconstitution.

TL;DR: A 6-year-old Iraqi Chaldean girl with bilateral ocular and facial telangiectasia, recurrent sinorespiratory infections since infancy, bronchiectasis, and immunodeficiency presenting as hyper IgM syndrome (HIGM) was diagnosed with AT and in depth neurological testing showed subtle anomalies as mild dysarthria and axial ataxia without appendicular atAXia that were unapparent on multiple previous clinical evaluations.

TL;DR: The findings show that CD34–CD45 IHC improves reproducibility of MVI scoring and facilitates MVI quantification and introduction of a dual anti‐CD34/CD45 has the potential to improve recognition of M VI ahead of DSA results.

TL;DR: Serum biochemical and serological changes were associated with amelioration of hepatic injury and a decrease (but not a disappearance) in hepatic HDAg on liver biopsy.

TL;DR: Interestingly, an increasing tumor cell clonality was tightly linked to patients’ prognosis, accompanied by a polarized immune cell landscape, and osteopontin was identified as a key player for tumor cell evolution and microenvironmental reprogramming.