M
Michael C. Kelly
Researcher at National Institutes of Health
Publications - 61
Citations - 6331
Michael C. Kelly is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hair cell & Medicine. The author has an hindex of 20, co-authored 49 publications receiving 4815 citations. Previous affiliations of Michael C. Kelly include Leidos & Miltenyi Biotec.
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Journal ArticleDOI
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Tom Dull,Romain Zufferey,Michael C. Kelly,Ronald J. Mandel,Matthew Nguyen,Didier Trono,Luigi Naldini +6 more
TL;DR: It is demonstrated that the requirement for the tat gene can be offset by placing constitutive promoters upstream of the vector transcript, and the improved design presented here should facilitate testing of lentivirus vectors.
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Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer
Lichun Ma,Maria O. Hernandez,Yongmei Zhao,Monika Mehta,Bao Tran,Michael C. Kelly,Zachary Rae,Jonathan M. Hernandez,Jeremy L. Davis,Sean P. Martin,David E. Kleiner,Stephen M. Hewitt,Kris Ylaya,Bradford J. Wood,Tim F. Greten,Xin Wei Wang +15 more
TL;DR: This work determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients and found a link between hypoxia-dependent vascular endothelial growth factor expression in tumor diversity and TME polarization.
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Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior.
Anupama Sathyamurthy,Kory R. Johnson,Kaya J.E. Matson,Courtney I. Dobrott,Li Li,Anna R. Ryba,Tzipporah B. Bergman,Michael C. Kelly,Matthew W. Kelley,Ariel J. Levine +9 more
TL;DR: This work used massively parallel single nucleus RNA sequencing (snRNA-seq) to create an atlas of the adult mouse lumbar spinal cord and identified and molecularly characterized 43 neuronal populations that were active following a sensory and a motor behavior.
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Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
Sri Krishna,Frank J. Lowery,Amy R. Copeland,Erol Bahadiroglu,Ratnadeep Mukherjee,Li Jia,James T. Anibal,Abraham Sachs,Serifat Adebola,Devikala Gurusamy,Zhiya Yu,Victoria Hill,Jared J. Gartner,Yong F. Li,Maria R. Parkhurst,Biman C. Paria,Pia Kvistborg,Michael C. Kelly,Stephanie L. Goff,Grégoire Altan-Bonnet,Paul F. Robbins,Steven A. Rosenberg +21 more
TL;DR: Tumor-reactive stem-like TILs were capable of self-renewal, expansion, persistence, and superior antitumor response in vivo, suggesting that Til subsets mediating ACT response are distinct from TIL subsets enriched for antitumors reactivity.
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Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear
TL;DR: Comparisons of cell types from utricles and cochleae demonstrate divergence between auditory and vestibular cells, despite a common origin, and suggest possible plasticity among cells at the sensory–nonsensory boundary.