D
Dennis D. Hickstein
Researcher at National Institutes of Health
Publications - Â 126
Citations - Â 6258
Dennis D. Hickstein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hematopoietic stem cell transplantation & Leukocyte adhesion deficiency. The author has an hindex of 34, co-authored 120 publications receiving 5545 citations. Previous affiliations of Dennis D. Hickstein include United States Department of Veterans Affairs & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity
Michael A. Spinner,Lauren A. Sanchez,Amy P. Hsu,Pamela A. Shaw,Christa S. Zerbe,Katherine R. Calvo,Diane C. Arthur,Wenjuan Gu,Christine M. Gould,Carmen C. Brewer,Edward W. Cowen,Alexandra F. Freeman,Kenneth N. Olivier,Gulbu Uzel,Adrian M. Zelazny,Janine Daub,Christine Spalding,Reginald J. Claypool,Neelam Giri,Blanche P. Alter,Emily M. Mace,Jordan S. Orange,Jennifer Cuellar-Rodriguez,Dennis D. Hickstein,Steven M. Holland +24 more
TL;DR: GATA2 deficiency unites susceptibility to MDS/AML, immunodeficiency, pulmonary disease, and vascular/lymphatic dysfunction, and monocytopenia, B, NK, and CD4 lymphocy topenia correlated with the presence of disease.
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Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome
Amy P. Hsu,Elizabeth P. Sampaio,Javed Khan,Katherine R. Calvo,Jacob E. Lemieux,Smita Y. Patel,David M. Frucht,Donald C. Vinh,Roger D. Auth,Alexandra F. Freeman,Kenneth N. Olivier,Gulbu Uzel,Christa S. Zerbe,Christine Spalding,Stefania Pittaluga,Mark Raffeld,Douglas B. Kuhns,Li Ding,Michelle L. Paulson,Michelle L. Paulson,Beatriz E. Marciano,Juan Gea-Banacloche,Jordan S. Orange,Jennifer Cuellar-Rodriguez,Dennis D. Hickstein,Steven M. Holland +25 more
TL;DR: GATA2 joins RUNX1 and CEBPA not only as a familial leukemia gene but also as a cause of a complex congenital immunodeficiency that evolves over decades and combines predisposition to infection and myeloid malignancy.
Journal ArticleDOI
Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation.
James N. Kochenderfer,Mark E. Dudley,Robert O. Carpenter,Sadik H. Kassim,Jeremy J. Rose,William G. Telford,Frances T. Hakim,David Halverson,Daniel H. Fowler,Nancy M. Hardy,Anthony R. Mato,Dennis D. Hickstein,Juan Gea-Banacloche,Steven Z. Pavletic,Claude Sportes,Irina Maric,Steven A. Feldman,Brenna Hansen,Jennifer Wilder,Bazetta Blacklock-Schuver,Bipulendu Jena,Michael R. Bishop,Ronald E. Gress,Steven A. Rosenberg +23 more
TL;DR: Results show for the first time that donor-derived allogeneic anti-CD19-CAR T cells can cause regression of B-cell malignancies resistant to standard DLIs without causing GVHD.
Journal ArticleDOI
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.
Liu Yang,Li Xia,Daniel Y. Wu,Hengbin Wang,Howard A. Chansky,William H. Schubach,Dennis D. Hickstein,Yi Zhang +7 more
TL;DR: It is demonstrated that ESET is a histone H3-specific methyltransferase, and that mutations within ESET abolished its methyl transferase activity, raising the possibility that transcription factor ERG may participate in transcriptional regulation through ESET-mediated histone methylation.
Journal ArticleDOI
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature
Jan Kazenwadel,Genevieve A. Secker,Yajuan J. Liu,Jill A. Rosenfeld,Robert S. Wildin,Jennifer Cuellar-Rodriguez,Amy P. Hsu,Sarah Dyack,Conrad V. Fernandez,Chan Eng Chong,Chan Eng Chong,Milena Babic,Peter G Bardy,Akiko Shimamura,Akiko Shimamura,Michael Y. Zhang,Michael Y. Zhang,Tom Walsh,Steven M. Holland,Dennis D. Hickstein,Marshall S. Horwitz,Christopher N. Hahn,Christopher N. Hahn,Hamish S. Scott,Hamish S. Scott,Natasha L. Harvey,Natasha L. Harvey +26 more
TL;DR: It is demonstrated here that GATA2 protein is present at high levels in lymphatic vessel valves and that Gata2 controls the expression of genes important for programming lymphatic valve development.