S
Sean Proll
Researcher at University of Washington
Publications - 80
Citations - 7517
Sean Proll is an academic researcher from University of Washington. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 41, co-authored 72 publications receiving 6963 citations. Previous affiliations of Sean Proll include Fred Hutchinson Cancer Research Center & Washington University in St. Louis.
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Journal ArticleDOI
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
Mary E. Brunkow,Jessica Gardner,Jeff Van Ness,Bryan W. Paeper,Brian Kovacevich,Sean Proll,John E. Skonier,L. Zhao,P.J. Sabo,Ying-Hui Fu,Reid S. Alisch,Lucille Gillett,Trenton Colbert,Paolo Tacconi,David J. Galas,Herman Hamersma,Peter Beighton,John T. Mulligan +17 more
TL;DR: The specific and progressive effect on bone formation observed in individuals affected with sclerosteosis, along with the data presented in this study, together suggest that the SOST gene encodes an important new regulator of bone homeostasis.
Journal ArticleDOI
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
John C. Kash,Terrence M. Tumpey,Sean Proll,Victoria S. Carter,Olivia Perwitasari,Matthew J. Thomas,Christopher F. Basler,Peter Palese,Jeffery K. Taubenberger,Jeffery K. Taubenberger,Adolfo García-Sastre,David E. Swayne,Michael G. Katze +12 more
TL;DR: It is found that mice infected with a virus containing all eight genes from the pandemic virus showed marked activation of pro-inflammatory and cell-death pathways by 24 h after infection that remained unabated until death on day 5, in contrast with smaller host immune responses as measured at the genomic level.
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Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
David Favre,Sharon Lederer,Bittoo Kanwar,Zhong-Min Ma,Sean Proll,Zeljka Kasakow,Jeff E. Mold,Louise A. Swainson,Jason D. Barbour,Carole R. Baskin,Robert E. Palermo,Ivona Pandrea,Christopher J. Miller,Michael G. Katze,Joseph M. McCune +14 more
TL;DR: Comparing acute pathogenic SIV infection in pigtailed macaques to non-pathogenic infection in African green monkeys indicates that loss of the Th17 to Treg balance is related to SIV disease progression.
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Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics.
Deborah L. Diamond,Andrew J. Syder,Jon M. Jacobs,Christina M. Sorensen,Kathie-Anne Walters,Sean Proll,Jason E. McDermott,Marina A. Gritsenko,Qibin Zhang,Rui Zhao,Thomas O. Metz,David G. Camp,Katrina M. Waters,Richard D. Smith,Charles M. Rice,Michael G. Katze +15 more
TL;DR: In this paper, the authors performed proteomic and lipidomic profiling over a time course of acute hepatitis C virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular processes influenced by this virus.
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Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus
Carole R. Baskin,Helle Bielefeldt-Ohmann,Terrence M. Tumpey,Patrick J. Sabourin,James P. Long,Adolfo García-Sastre,Airn-E. Tolnay,Randy A. Albrecht,John A. Pyles,Pam H. Olson,Lauri D. Aicher,Elizabeth Rosenzweig,Kaja Murali-Krishna,Edward A. Clark,Mark S. Kotur,Jamie L. Fornek,Sean Proll,Robert E. Palermo,Carol L. K. Sabourin,Michael G. Katze +19 more
TL;DR: The H5N1 virus was exceptional for the extent of tissue damage, cytokinemia, and interference with immune regulatory mechanisms, which may help explain the extreme virulence of HPAI viruses in humans.