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Patricia V. Aguilar

Researcher at University of Texas Medical Branch

Publications -  79
Citations -  12288

Patricia V. Aguilar is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Virus & Alphavirus. The author has an hindex of 36, co-authored 72 publications receiving 9759 citations. Previous affiliations of Patricia V. Aguilar include Naval Medical Research Unit Six & Naval Medical Research Center.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Characterization of the reconstructed 1918 Spanish influenza pandemic virus

Terrence M. Tumpey, +10 more
- 07 Oct 2005 - 
TL;DR: Reverse genetics was used to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence, and confirmed that the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemicirus.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

An infectious cDNA clone of SARS-CoV-2

Xuping Xie, +15 more
- 13 May 2020 - 
TL;DR: The reverse genetic system and reporter virus provide key reagents to study SARS-CoV-2 and develop countermeasures and were successfully used to evaluate the antiviral activities of interferon (IFN).
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Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.

Bryan A. Johnson, +32 more
- 25 Jan 2021 - 
TL;DR: In this paper, a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA) was generated, which had faster kinetics, improved fitness in Vero E6 cells and reduced spike protein processing.