D
David Grundy
Researcher at University of Sheffield
Publications - 247
Citations - 10833
David Grundy is an academic researcher from University of Sheffield. The author has contributed to research in topics: Vagus nerve & Receptor. The author has an hindex of 53, co-authored 247 publications receiving 9991 citations. Previous affiliations of David Grundy include Northern General Hospital & Queen's University.
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Principles and standards for reporting animal experiments in The Journal of Physiology and Experimental Physiology.
TL;DR: Detailed guidelines for how authors should report experimental procedures that involve animals are set out to facilitate the review process and decision making where there are questions regarding animal ethics.
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Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Giovanni Barbara,Bingxian Wang,Vincenzo Stanghellini,Roberto De Giorgio,Cesare Cremon,Giovanni Di Nardo,Marcello Trevisani,Barbara Campi,Pierangelo Geppetti,Marcello Tonini,Nigel W. Bunnett,David Grundy,Roberto Corinaldesi +12 more
TL;DR: Mucosal mast cell mediators from IBS patients excite rat nociceptive visceral sensory nerves in vitro, providing new insights into the mechanism underlying visceral hypersensitivity in IBS.
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Fundamentals of neurogastroenterology: Basic science
Stephen J. Vanner,Beverley Greenwood-Van Meerveld,Gary M. Mawe,Terez Shea-Donohue,Elena F. Verdu,Jackie D. Wood,David Grundy +6 more
TL;DR: This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs) and emphasizes recent advances in understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways.
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Sensory transmission in the gastrointestinal tract
TL;DR: The purpose of this review is to summarize current views on sensory processing within both the enteric and extrinsic innervation and to specifically address the pharmacology of nociceptive extrinsics sensory pathways.
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Neuroanatomy of visceral nociception: vagal and splanchnic afferent
TL;DR: It is likely that vagal and splanchnic afferents play different roles in mediating sensation because of the different response profiles following activation of these pathways.