David I. Wasserman

TL;DR: A circuit model that links VTA and RMTg GABA with LDTg and PPTg neurons critical for DA‐dependent opioid effects in drug‐naïve rodents is proposed and hypothesized to lead to arousing and rewarding effects through disinhibition of VTA DA neurons.

TL;DR: An integration of touchscreen cognitive testing with an open-access database public repository, as well as a Web platform for knowledge dissemination, envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.

TL;DR: The finding that exposure to USV‐emitting pups increased plasma prolactin levels in WT dams but not in D2R KO dams, and KO dams showed delayed pup retrieval and nest building further support the role of D 2R signalling in maternal care.

TL;DR: M5 muscarinic acetylcholine receptors expressed on ventral tegmental dopamine neurons are needed for opioid activation of DA outputs and decreasing morphine‐induced locomotion was decreased by M5 receptor gene expression in RMTg GABA neurons that directly inhibit VTA DA neurons.

TL;DR: It is proposed that cholinergic inhibition of rostromedial tegmental GABA neurons via M4 muscarinic receptors facilitates opioid inhibition of the same neurons.