V
Vania F. Prado
Researcher at University of Western Ontario
Publications - 130
Citations - 6041
Vania F. Prado is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Cholinergic & Acetylcholine. The author has an hindex of 39, co-authored 119 publications receiving 4987 citations. Previous affiliations of Vania F. Prado include Universidade Federal de Minas Gerais & University of California, Santa Barbara.
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Journal ArticleDOI
The ancestry of Brazilian mtDNA lineages.
Juliana Alves-Silva,Magda S. Santos,Pedro Edson Moreira Guimarães,Alessandro C. S. Ferreira,Hans-Jürgen Bandelt,Sérgio D.J. Pena,Vania F. Prado +6 more
TL;DR: The mtDNA pool of present-day Brazilians clearly reflects the imprints of the early Portuguese colonization process (involving directional mating), as well as the recent immigrant waves (from Europe) of the last century.
Journal ArticleDOI
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Mychael V. Lourenco,Mychael V. Lourenco,Rudimar Luiz Frozza,Rudimar Luiz Frozza,Guilherme B. L. de Freitas,Guilherme B. L. de Freitas,Hong Zhang,Grasielle C. Kincheski,Felipe C. Ribeiro,Rafaella Araujo Gonçalves,Julia R. Clarke,Danielle Beckman,Agnieszka Staniszewski,Hanna Berman,Lorena A. Guerra,Leticia Forny-Germano,Shelby E. Meier,Donna M. Wilcock,Jorge Marcondes de Souza,Soniza Vieira Alves-Leon,Vania F. Prado,Marco A. M. Prado,Jose F. Abisambra,Fernanda Tovar-Moll,Paulo Mattos,Ottavio Arancio,Sergio T. Ferreira,Fernanda G. De Felice,Fernanda G. De Felice +28 more
TL;DR: FNDC5/irisin is placed as a novel agent capable of opposing synapse failure and memory impairment in AD, and restoration of its expression can ameliorate these phenotypes in rodent models.
Journal ArticleDOI
The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases.
Rachel E. Lackie,Andrzej Maciejewski,Valeriy G. Ostapchenko,Jose Marques-Lopes,Wing-Yiu Choy,Martin L. Duennwald,Vania F. Prado,Marco A. M. Prado +7 more
TL;DR: The role of intracellular and extracellular STI1 and the Hsp70/Hsp90 chaperone network in mechanisms underlying protein misfolding in neurodegenerative diseases, with particular focus on AD is discussed.
Journal ArticleDOI
Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition
Vania F. Prado,Cristina Martins-Silva,Braulio M. de Castro,Ricardo F. Lima,Daniela M. Barros,Ernani Amaral,Amy J. Ramsey,Tatyana D. Sotnikova,Maria Rosana Ramirez,Hyung-Gun Kim,Janine I. Rossato,Janaina Koenen,Hui Quan,Vinícius Rosa Cota,Márcio Flávio Dutra Moraes,Marcus Vinicius Gomez,Cristina Guatimosim,William C. Wetsel,Christopher Kushmerick,Grace S. Pereira,Raul R. Gainetdinov,Ivan Izquierdo,Marc G. Caron,Marco A. M. Prado +23 more
TL;DR: In this paper, the vesicular storage of acetylcholine (ACh) was found to be a critical step for cholinergic transmission in the peripheral and central nervous system.
Journal ArticleDOI
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity.
Miao Jing,Li Y,Li Y,Jianzhi Zeng,Jianzhi Zeng,Pengcheng Huang,Miguel Skirzewski,Ornela Kljakic,Wanling Peng,Tongrui Qian,Tongrui Qian,Ke Tan,Ke Tan,Jing Zou,Simon Trinh,Wu Runlong,Shichen Zhang,Shichen Zhang,Sunlei Pan,Sunlei Pan,Samuel Andrew Hires,Min Xu,Haohong Li,Lisa M. Saksida,Vania F. Prado,Timothy J. Bussey,Marco A. M. Prado,Liangyi Chen,Heping Cheng,Heping Cheng,Yulong Li,Yulong Li +31 more
TL;DR: The GRAB ACh (GPCR-activation-based ACh) sensor is optimized to achieve substantially improved sensitivity in ACh detection, as well as reduced downstream coupling to intracellular pathways.