M
Mohammed A. Al-Onaizi
Researcher at University of Western Ontario
Publications - 20
Citations - 482
Mohammed A. Al-Onaizi is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Cholinergic & Acetylcholine. The author has an hindex of 10, co-authored 16 publications receiving 346 citations. Previous affiliations of Mohammed A. Al-Onaizi include Kuwait University & Laval University.
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Journal ArticleDOI
Cholinergic circuits in cognitive flexibility.
TL;DR: Strong evidence indicates that cholinergic interneurons from the dorsomedial striatum are essential for facilitating the establishment of a new selected strategy; an effect that seems to depend mainly on activation of muscarinic receptors.
Journal ArticleDOI
Forebrain Deletion of the Vesicular Acetylcholine Transporter Results in Deficits in Executive Function, Metabolic, and RNA Splicing Abnormalities in the Prefrontal Cortex
Benjamin Kolisnyk,Mohammed A. Al-Onaizi,Pedro H. F. Hirata,Monica S. Guzman,Simona Nikolova,Shahar Barbash,Hermona Soreq,Robert Bartha,Robert Bartha,Marco A. M. Prado,Vania F. Prado +10 more
TL;DR: It is proposed that VAChT-targeted mice can be used to model and to dissect the neurochemical basis of executive abnormalities, and altered levels of two neurochemical markers of neuronal function, taurine and lactate, are shown, suggesting altered PFC metabolism in VA cholinergic-deficient mice.
Journal ArticleDOI
Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation
Kurt Lehner,Harold A. Silverman,Harold A. Silverman,Meghan E. Addorisio,Ashbeel Roy,Mohammed A. Al-Onaizi,Mohammed A. Al-Onaizi,Yaakov A. Levine,Peder S. Olofsson,Peder S. Olofsson,Sangeeta S. Chavan,Sangeeta S. Chavan,Robert Gros,Neil M. Nathanson,Yousef Al-Abed,Christine N. Metz,Christine N. Metz,Vania F. Prado,Marco A. M. Prado,Kevin J. Tracey,Kevin J. Tracey,Valentin A. Pavlov,Valentin A. Pavlov +22 more
TL;DR: The findings reveal that forebrain cholinergic neurons regulate innate immune responses and inflammation, suggesting the possibility that in diseases associated with cholinergy dysfunction, including Alzheimer's disease this anti-inflammatory regulation can be impaired.
Journal ArticleDOI
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
Benjamin Kolisnyk,Mohammed A. Al-Onaizi,Mohammed A. Al-Onaizi,Lilach Soreq,Shahar Barbash,Uriya Bekenstein,Nejc Haberman,Geula Hanin,Maxine T. Kish,Jussemara Souza da Silva,Margaret Fahnestock,Jernej Ule,Hermona Soreq,Vania F. Prado,Marco A. M. Prado +14 more
TL;DR: It is suggested that changes in RNA processing caused by cholinergic loss can facilitate Alzheimer's-like pathology in mice, providing a mechanism by which decreased Cholinergic tone may increase risk of dementia.
Journal ArticleDOI
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone
Mohammed A. Al-Onaizi,Gustavo M. Parfitt,Benjamin Kolisnyk,Clayton S. H. Law,Monica S. Guzman,Monica S. Guzman,Daniela M. Barros,L. Stan Leung,Marco A. M. Prado,Vania F. Prado +9 more
TL;DR: A refined roadmap of how synaptically secreted acetylcholine influences distinct behaviors is provided and suggests that distinct forms of cognitive processing may be regulated in different ways by cholinergic activity.