M
Marco A. M. Prado
Researcher at University of Western Ontario
Publications - 226
Citations - 8231
Marco A. M. Prado is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Cholinergic & Acetylcholine. The author has an hindex of 47, co-authored 212 publications receiving 6962 citations. Previous affiliations of Marco A. M. Prado include University of California, Santa Barbara & McGill University.
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Journal ArticleDOI
Physiology of the Prion Protein
Rafael Linden,Vilma R. Martins,Marco A. M. Prado,Martín Cammarota,Ivan Izquierdo,Ricardo R. Brentani +5 more
TL;DR: A unified view of functional properties of PrP(C) indicates that the prion protein is a dynamic cell surface platform for the assembly of signaling modules, based on which selective interactions with many ligands and transmembrane signaling pathways translate into wide-range consequences upon both physiology and behavior.
Journal ArticleDOI
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Mychael V. Lourenco,Mychael V. Lourenco,Rudimar Luiz Frozza,Rudimar Luiz Frozza,Guilherme B. L. de Freitas,Guilherme B. L. de Freitas,Hong Zhang,Grasielle C. Kincheski,Felipe C. Ribeiro,Rafaella Araujo Gonçalves,Julia R. Clarke,Danielle Beckman,Agnieszka Staniszewski,Hanna Berman,Lorena A. Guerra,Leticia Forny-Germano,Shelby E. Meier,Donna M. Wilcock,Jorge Marcondes de Souza,Soniza Vieira Alves-Leon,Vania F. Prado,Marco A. M. Prado,Jose F. Abisambra,Fernanda Tovar-Moll,Paulo Mattos,Ottavio Arancio,Sergio T. Ferreira,Fernanda G. De Felice,Fernanda G. De Felice +28 more
TL;DR: FNDC5/irisin is placed as a novel agent capable of opposing synapse failure and memory impairment in AD, and restoration of its expression can ameliorate these phenotypes in rodent models.
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The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases.
Rachel E. Lackie,Andrzej Maciejewski,Valeriy G. Ostapchenko,Jose Marques-Lopes,Wing-Yiu Choy,Martin L. Duennwald,Vania F. Prado,Marco A. M. Prado +7 more
TL;DR: The role of intracellular and extracellular STI1 and the Hsp70/Hsp90 chaperone network in mechanisms underlying protein misfolding in neurodegenerative diseases, with particular focus on AD is discussed.
Journal ArticleDOI
Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition
Vania F. Prado,Cristina Martins-Silva,Braulio M. de Castro,Ricardo F. Lima,Daniela M. Barros,Ernani Amaral,Amy J. Ramsey,Tatyana D. Sotnikova,Maria Rosana Ramirez,Hyung-Gun Kim,Janine I. Rossato,Janaina Koenen,Hui Quan,Vinícius Rosa Cota,Márcio Flávio Dutra Moraes,Marcus Vinicius Gomez,Cristina Guatimosim,William C. Wetsel,Christopher Kushmerick,Grace S. Pereira,Raul R. Gainetdinov,Ivan Izquierdo,Marc G. Caron,Marco A. M. Prado +23 more
TL;DR: In this paper, the vesicular storage of acetylcholine (ACh) was found to be a critical step for cholinergic transmission in the peripheral and central nervous system.
Journal ArticleDOI
An optimized acetylcholine sensor for monitoring in vivo cholinergic activity.
Miao Jing,Li Y,Li Y,Jianzhi Zeng,Jianzhi Zeng,Pengcheng Huang,Miguel Skirzewski,Ornela Kljakic,Wanling Peng,Tongrui Qian,Tongrui Qian,Ke Tan,Ke Tan,Jing Zou,Simon Trinh,Wu Runlong,Shichen Zhang,Shichen Zhang,Sunlei Pan,Sunlei Pan,Samuel Andrew Hires,Min Xu,Haohong Li,Lisa M. Saksida,Vania F. Prado,Timothy J. Bussey,Marco A. M. Prado,Liangyi Chen,Heping Cheng,Heping Cheng,Yulong Li,Yulong Li +31 more
TL;DR: The GRAB ACh (GPCR-activation-based ACh) sensor is optimized to achieve substantially improved sensitivity in ACh detection, as well as reduced downstream coupling to intracellular pathways.