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David J. FitzGerald
Researcher at Laboratory of Molecular Biology
Publications - 229
Citations - 14335
David J. FitzGerald is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Pseudomonas exotoxin & Immunotoxin. The author has an hindex of 63, co-authored 225 publications receiving 13887 citations. Previous affiliations of David J. FitzGerald include Genentech & Government of the United States of America.
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Journal ArticleDOI
Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia
Robert J. Kreitman,Wyndham H. Wilson,Karen Bergeron,Miranda Raggio,Maryalice Stetler-Stevenson,David J. FitzGerald,Ira Pastan +6 more
TL;DR: BL22 can induce complete remissions in patients with hairy-cell leukemia that is resistant to treatment with purine analogues, including cladribine.
Journal ArticleDOI
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
Waleed Haso,Daniel W. Lee,Nirali N. Shah,Maryalice Stetler-Stevenson,Constance M. Yuan,Ira Pastan,Dimiter S. Dimitrov,Richard A. Morgan,David J. FitzGerald,David M. Barrett,Alan S. Wayne,Alan S. Wayne,Crystal L. Mackall,Rimas J. Orentas +13 more
TL;DR: It is concluded that second-generation m971 mAb-derived anti-CD22 CARs are promising novel therapeutics that should be tested in BCP-ALL.
Journal ArticleDOI
Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.
TL;DR: Toxin lacking domain Ia is about 100-fold less toxic to mice than intact PE and should be a useful molecule for the construction of immunotoxins.
Journal ArticleDOI
Immunotoxin Therapy of Cancer
TL;DR: Results from clinical trials indicate that recombinant immunotoxins and similar agents that are designed to combine antibody selectivity with toxin cell-killing potency will be useful additions to cancer therapy.
Journal ArticleDOI
Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis
Paula J. Wilderman,Nathaniel A. Sowa,David J. FitzGerald,Peter C. FitzGerald,Susan Gottesman,Urs A. Ochsner,Michael L. Vasil +6 more
TL;DR: The identification of two tandem sRNAs in P. aeruginosa that were candidates for functional homologs of RyhB suggest that the role of s RNAs in bacterial iron homeostasis may be broad, and approaches similar to those described here may identify these sRNA in other organisms.