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David J. Lythgoe
Researcher at King's College London
Publications - 134
Citations - 4974
David J. Lythgoe is an academic researcher from King's College London. The author has contributed to research in topics: Psychosis & Glutamate receptor. The author has an hindex of 32, co-authored 108 publications receiving 3969 citations. Previous affiliations of David J. Lythgoe include University of London & South London and Maudsley NHS Foundation Trust.
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Journal ArticleDOI
Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis
Michael O'Sullivan,David J. Lythgoe,Andreia Pereira,Paul Summers,Josef Jarosz,Steven Williams,Hugh S. Markus +6 more
TL;DR: Hypoperfusion may be an early feature in the development of periventricular lesions in ILA and may play a direct pathogenic role, and Serial studies are now needed to determine whether these changes herald the appearance of new lesions and represent ‘at risk’ white matter, and whether pharmacological agents can restore perfusion of normal-appearing white matter.
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Common and Distinct Neural Substrates for Pragmatic, Semantic, and Syntactic Processing of Spoken Sentences: An fMRI Study
Gina R. Kuperberg,Philip McGuire,Edward T. Bullmore,Mick Brammer,Sophia Rabe-Hesketh,Ian C. Wright,David J. Lythgoe,Steven Williams,A.S. David +8 more
TL;DR: It is suggested that the left-inferior-temporal/fusiform gyrus may play a key role in using pragmatic, semantic, and subcategorical information to construct a higher representation of meaning of sentences.
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Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI
Derek K. Jones,David J. Lythgoe,Mark A. Horsfield,Andrew Simmons,Steve C.R. Williams,Hugh S. Markus +5 more
TL;DR: The characteristic pattern found on diffusion tensor imaging in this patient group is consistent with axonal loss and gliosis leading to impairment to and loss of directional diffusion in leukoaraiosis.
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Glutamate Dysfunction in People with Prodromal Symptoms of Psychosis: Relationship to Gray Matter Volume
James M. Stone,Fern Day,Helen Tsagaraki,Isabel Valli,Mary A. McLean,David J. Lythgoe,Ruth L. O'Gorman,Gareth J. Barker,Philip McGuire,Oasis +9 more
TL;DR: This study provides the first evidence that brain glutamate function is perturbed in people with prodromal signs of schizophrenia and that glutamatergic dysfunction is associated with a reduction in gray matter volume in brain regions thought to be critical to the pathogenesis of the disorder.
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A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust.
Mary L. Phillips,Isaac Marks,Carl Senior,David J. Lythgoe,A M O'Dwyer,Meehan O,Steven Williams,Michael Brammer,Edward T. Bullmore,Philip McGuire +9 more
TL;DR: Only washers demonstrate a neural response to washer-relevant disgust associated with emotion perception rather than attention to non-emotive visual detail, and this response is distinguished between washing and checking symptoms in OCD.