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David J. Lythgoe

Researcher at King's College London

Publications -  134
Citations -  4974

David J. Lythgoe is an academic researcher from King's College London. The author has contributed to research in topics: Psychosis & Glutamate receptor. The author has an hindex of 32, co-authored 108 publications receiving 3969 citations. Previous affiliations of David J. Lythgoe include University of London & South London and Maudsley NHS Foundation Trust.

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Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis

TL;DR: Hypoperfusion may be an early feature in the development of periventricular lesions in ILA and may play a direct pathogenic role, and Serial studies are now needed to determine whether these changes herald the appearance of new lesions and represent ‘at risk’ white matter, and whether pharmacological agents can restore perfusion of normal-appearing white matter.
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Common and Distinct Neural Substrates for Pragmatic, Semantic, and Syntactic Processing of Spoken Sentences: An fMRI Study

TL;DR: It is suggested that the left-inferior-temporal/fusiform gyrus may play a key role in using pragmatic, semantic, and subcategorical information to construct a higher representation of meaning of sentences.
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Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI

TL;DR: The characteristic pattern found on diffusion tensor imaging in this patient group is consistent with axonal loss and gliosis leading to impairment to and loss of directional diffusion in leukoaraiosis.
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Glutamate Dysfunction in People with Prodromal Symptoms of Psychosis: Relationship to Gray Matter Volume

TL;DR: This study provides the first evidence that brain glutamate function is perturbed in people with prodromal signs of schizophrenia and that glutamatergic dysfunction is associated with a reduction in gray matter volume in brain regions thought to be critical to the pathogenesis of the disorder.
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A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust.

TL;DR: Only washers demonstrate a neural response to washer-relevant disgust associated with emotion perception rather than attention to non-emotive visual detail, and this response is distinguished between washing and checking symptoms in OCD.