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David J. Rozansky
Researcher at Oregon Health & Science University
Publications - 22
Citations - 1192
David J. Rozansky is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Chromogranin A & SGK1. The author has an hindex of 14, co-authored 21 publications receiving 1091 citations. Previous affiliations of David J. Rozansky include University of California, San Diego & University of California, San Francisco.
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Journal ArticleDOI
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.
Jian Wang,Pascal Barbry,Anita C. Maiyar,David J. Rozansky,Aditi Bhargava,Meredith L. Leong,Gary L. Firestone,David A. Pearce +7 more
TL;DR: It is shown that PI3K is required for SGK-dependent stimulation of ENaC-mediated Na+ transport as well as for the production of the phosphorylated form of SGK, which suggests that SGK is a PI3k-dependent integrator of insulin and mineralocorticoid actions that interacts with EN aC subunits to control Na+ entry into kidney collecting duct cells.
Journal ArticleDOI
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway
David J. Rozansky,Tonya Cornwall,Arohan R. Subramanya,Arohan R. Subramanya,Shaunessy Rogers,Yong Feng Yang,Larry L. David,Xiaoman Zhu,Chao Ling Yang,David H. Ellison +9 more
TL;DR: Measurement of sodium uptake in a Xenopus oocyte expression system found that serum and glucocorticoid-induced kinase 1 (SGK1), an aldosterone-responsive gene expressed in the DN, attenuated the inhibitory effect of WNK4 on NCC activity.
Journal ArticleDOI
Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression.
TL;DR: The results suggest that this complex gene is encoded by exon modules with evolutionary links to homologous modules in other chromogranin/secretogran in protein family members, and that the 5'-flanking region of the gene is sufficient to confer neuroendocrine tissue-specific expression of the chromogrannin A gene.
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Acute kidney injury associated with smoking synthetic cannabinoid.
G. L. Buser,Roy Gerona,B Z Horowitz,K. P. Vian,Megan L. Troxell,Robert G. Hendrickson,D. C. Houghton,David J. Rozansky,S. W. Su,Richard Leman +9 more
TL;DR: The epidemiology of a toxicologic syndrome of acute kidney injury associated with synthetic cannabinoids is described, the toxicologic and public health investigation of the cluster is reviewed, and clinical implications of the Cluster investigation are described.
Journal ArticleDOI
The impact of short stature on health-related quality of life in children with chronic kidney disease.
Amira Al-Uzri,Matthew B. Matheson,Debbie S. Gipson,Susan R. Mendley,Stephen R. Hooper,Ora Yadin,David J. Rozansky,Marva Moxey-Mims,Susan L. Furth,Bradley A. Warady,Arlene C. Gerson +10 more
TL;DR: In this paper, the authors compared the health-related quality of life (HRQoL) of children with chronic kidney disease (CKD) and short stature (SS) with children with normal height (NH) and their parents.