David Lagorce

TL;DR: Recent major extensions of the Human Phenotype Ontology for neurology, nephrology, immunology, pulmonology, newborn screening, and other areas are presented and new efforts to harmonize computational definitions of phenotypic abnormalities across the HPO and multiple phenotype ontologies used for animal models of disease are presented.

TL;DR: It was found that both the inositol 1,4,5-triphosphate receptor gene and the telomerase gene were targeted by HBV in two different tumors, indicating that HBV frequently targets cellular genes involved in cell signalling and some of them may be preferential targets of the viral integration.

TL;DR: It is demonstrated that HCV core deregulates the control of apoptosis by inducing ER stress and ER calcium depletion providing new elements to understand the mechanisms involved in HCV-related liver chronic diseases.

TL;DR: AF-Drugs2 is a command line utility program based on the open source chemistry toolkit OpenBabel that performs various physicochemical calculations, identifies key functional groups, some toxic and unstable molecules/functional groups and can provide several distribution diagrams of major physicochemical properties of the screened compound libraries.

TL;DR: FAF-Drugs3, a web server that can be used for drug discovery and chemical biology projects to help in preparing compound libraries and to assist decision-making during the hit selection/lead optimization phase is presented.