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David M. Belnap
Researcher at University of Utah
Publications - 63
Citations - 4556
David M. Belnap is an academic researcher from University of Utah. The author has contributed to research in topics: Capsid & Biology. The author has an hindex of 34, co-authored 57 publications receiving 4122 citations. Previous affiliations of David M. Belnap include Brigham Young University & National Institutes of Health.
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Journal ArticleDOI
Three-Dimensional Structure of Herpes Simplex Virus from Cryo-Electron Tomography
Kay Grünewald,Prashant Desai,Dennis C. Winkler,J. Bernard Heymann,J. Bernard Heymann,David M. Belnap,Wolfgang Baumeister,Alasdair C. Steven +7 more
TL;DR: Herpes simplex virus, a DNA virus of high complexity, consists of a nucleocapsid surrounded by the tegument—a protein compartment—and the envelope, which was seen to form an asymmetric cap in cryo–electron tomograms of isolated virions.
Journal ArticleDOI
Bsoft: image processing and molecular modeling for electron microscopy.
TL;DR: Bsoft is a software package written for image processing of electron micrographs, interpretation of reconstructions, molecular modeling, and general image processing that allows shell scripting of processes and allows subtasks to be distributed across multiple computers for concurrent processing.
Journal ArticleDOI
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer
Elissa D. Pastuzyn,Cameron E. Day,Rachel B. Kearns,Madeleine Kyrke-Smith,Andrew Taibi,John McCormick,Nathan Yoder,David M. Belnap,Simon Erlendsson,Simon Erlendsson,Dustin R. Morado,John A. G. Briggs,Cédric Feschotte,Jason D. Shepherd +13 more
TL;DR: It is shown that Arc self-assembles into virus-like capsids that encapsulate RNA that suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system.
Journal ArticleDOI
Molecular Tectonic Model of Virus Structural Transitions: the Putative Cell Entry States of Poliovirus
David M. Belnap,David J. Filman,Benes L. Trus,Naiqian Cheng,Frank P. Booy,James F. Conway,Stephen Curry,Chaitanya N. Hiremath,Simon K. Tsang,Alasdair C. Steven,James M. Hogle +10 more
TL;DR: The gaps at the sites where VP1, VP2, and VP3 subunits meet are plausible candidates for the emergence of VP4 and the N terminus ofVP1, and the implications of these observations are discussed for models in which the externalized components form a transmembrane pore through which viral RNA enters the infected cell.
Journal ArticleDOI
Three-dimensional structure of poliovirus receptor bound to poliovirus.
David M. Belnap,Brian M. McDermott,David J. Filman,Naiqian Cheng,Benes L. Trus,Harmon J. Zuccola,Vincent R. Racaniello,James M. Hogle,Alasdair C. Steven +8 more
TL;DR: The inferred pattern of virus-sPvr interactions accounts for most mutations that affect the binding of Pvr to poliovirus.