Optical tweezers use the forces exerted by a strongly focused beam of light to trap and move objects ranging in size from tens of nanometres to tens of micrometres. Since their introduction in 1986, the optical tweezer has become an important tool for research in the fields of biology, physical chemistry and soft condensed matter physics. Recent advances promise to take optical tweezers out of the laboratory and into the mainstream of manufacturing and diagnostics; they may even become consumer products. The next generation of single-beam optical traps offers revolutionary new opportunities for fundamental and applied research.

http://physics.nyu.edu/grierlab/nreview2c/nreview2c.pdf

A revolution in optical manipulation

Photonic crystal fibers guide light by corralling it within a periodic array of microscopic air holes that run along the entire fiber length Largely through their ability to overcome the limitations of conventional fiber optics—for example, by permitting low-loss guidance of light in a hollow core—these fibers are proving to have a multitude of important technological and scientific applications spanning many disciplines The result has been a renaissance of interest in optical fibers and their uses

https://science.sciencemag.org/content/sci/299/5605/358.full.pdf

Photonic crystal fibers

Bose-Einstein condensation (BEC) has been observed in a dilute gas of sodium atoms. A Bose-Einstein condensate consists of a macroscopic population of the ground state of the system, and is a coherent state of matter. In an ideal gas, this phase transition is purely quantum-statistical. The study of BEC in weakly interacting systems which can be controlled and observed with precision holds the promise of revealing new macroscopic quantum phenomena that can be understood from first principles.

Bose-Einstein condensation in a gas of sodium atoms

As they travel through space, some light beams rotate. Such light beams have angular momentum. There are two particularly important ways in which a light beam can rotate: if every polarization vector rotates, the light has spin; if the phase structure rotates, the light has orbital angular momentum (OAM), which can be many times greater than the spin. Only in the past 20 years has it been realized that beams carrying OAM, which have an optical vortex along the axis, can be easily made in the laboratory. These light beams are able to spin microscopic objects, give rise to rotational frequency shifts, create new forms of imaging systems, and behave within nonlinear material to give new insights into quantum optics.

/pdf/orbital-angular-momentum-origins-behavior-and-applications-1sv8qfuhrs.pdf

Orbital angular momentum: origins, behavior and applications

Internet data traffic capacity is rapidly reaching limits imposed by optical fiber nonlinear effects Having almost exhausted available degrees of freedom to orthogonally multiplex data, the possibility is now being explored of using spatial modes of fibers to enhance data capacity We demonstrate the viability of using the orbital angular momentum (OAM) of light to create orthogonal, spatially distinct streams of data-transmitting channels that are multiplexed in a single fiber Over 11 kilometers of a specially designed optical fiber that minimizes mode coupling, we achieved 400-gigabits-per-second data transmission using four angular momentum modes at a single wavelength, and 16 terabits per second using two OAM modes over 10 wavelengths These demonstrations suggest that OAM could provide an additional degree of freedom for data multiplexing in future fiber networks

http://science.sciencemag.org/content/sci/340/6140/1545.full.pdf

Terabit-Scale Orbital Angular Momentum Mode Division Multiplexing in Fibers

We report on the optical trapping of water droplets with a supercontinuum laser source. Droplet size is determined by observing the spectrum of the on-axis backscattered light. In contrast to to monochromatic trapping, the broad spectrum of the supercontinuum covers several resonances of the first excited Mie coefficients. A minimum value of Q ~0.16 for the trapping efficiency is estimated.

Optical trapping and spectral analysis of aerosols with a supercontiuum laser source.

The solid to liquid phase transition of n-alkanes with more than ten carbon atoms is an interesting phenomenon relevant to many fields, from cosmetics to automotive. Here we report Raman spectroscopy of tetradecane, pentadecane and hexadecane as a function of temperature. In order to gain information on the structural changes that the hydrocarbons undergo during melting, and to determine the temperature and the speed at which the phase change occurs, their temperature-dependent Raman spectra are acquired. The spectra are analysed not only with respect to frequency shifts, band widths, and intensity ratio of certain bands, but also using a principal component analysis. The spectroscopic data suggest that the solid to liquid phase transition in hexadecane, differently from tetradecane and pentadecane, is almost instantaneous. Tetradecane shows a slightly faster transition than pentadecane. In addition, a rotator phase as an intermediate state between the liquid and crystalline solid phases is identified in pentadecane. Different characteristic features in the solid spectra of the hydrocarbons relate tetradecane and hexadecane to a tryclinic crystalline structure, and pentadecane to an orthorhombic structure.

/pdf/intermediate-phases-during-solid-to-liquid-transitions-in-3limhcsppb.pdf

Intermediate phases during solid to liquid transitions in long-chain n-alkanes

Micron and sub-micron sized aerosol particles are captured, manipulated and characterised in a Bessel beam optical trap. Bright field microscopy and elastic light scattering measurements are used in combination to interrogate trapped particles and explore the optical landscape of the trap. We conclude that the Bessel trap has a number of advantages over optical tweezers in terms of characterisation of accumulation mode particles, manipulation of particles over macroscopic length scales and effective control of the gas phase. As such, the Bessel trap is a valuable addition to the aerosol optical toolkit.

Manipulation and characterisation of accumulation and coarse mode aerosol particles using a Bessel beam trap.

Metastatic prostate cancer resistant to hormonal manipulation is considered the advanced stage of the disease and leads to most cancer-related mortality. With new research focusing on modulating cancer growth, it is essential to understand the biochemical changes in cells that can then be exploited for drug discovery and for improving responsiveness to treatment. Raman spectroscopy has a high chemical specificity and can be used to detect and quantify molecular changes at the cellular level. Collection of large data sets generated from biological samples can be employed to form discriminatory algorithms for detection of subtle and early changes in cancer cells. The present study describes Raman finger printing of normal and metastatic hormone-resistant prostate cancer cells including analyses with principal component analysis and linear discrimination. Amino acid-specific signals were identified, especially loss of arginine band. Androgen-resistant prostate cancer cells presented a higher content of phenylalanine, tyrosine, DNA and Amide III in comparison to PNT2 cells, which possessed greater amounts of L-arginine and had a B conformation of DNA. The analysis utilized in this study could reliably differentiate the 2 cell lines (sensitivity 95%; specificity 88%).

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbio.201700166

Raman spectroscopy for accurately characterizing biomolecular changes in androgen-independent prostate cancer cells.

Experimental observations suggest that there are differences between the behavior of particles optically trapped in air and trapped in a liquid phase. We have modified the Mie-Debye spherical aberration theory to numerically simulate an aerosol optical trap in an attempt to explain and predict the differences. The model incorporates Mie scattering and a trapping beam focused through media of stratified refractive index. We show that geometrical optics cannot correctly describe the aerosol optical trap and that spherical aberration must be included. We qualitatively explain the observed phenomena before discussing the limits of the experimental techniques and methods to improve it. We conclude that the system does not behave as a true “optical tweezers,” varying between levitation and single beam gradient force trapping, depending on particle and beam parameters.

David McGloin

Papers

Optical trapping and spectral analysis of aerosols with a supercontiuum laser source.

Intermediate phases during solid to liquid transitions in long-chain n-alkanes

Manipulation and characterisation of accumulation and coarse mode aerosol particles using a Bessel beam trap.

Raman spectroscopy for accurately characterizing biomolecular changes in androgen-independent prostate cancer cells.

Modeling of optical traps for aerosols