David Petrik

TL;DR: This work introduces the “neurogenic interactome,” a platform from which to consider the diverse and dynamic factors regulating neurogenesis, and proposes consideration of the varying perspectives offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of Neurogenesis in the etiology and treatment of depression.

TL;DR: Co-expression of Bcl-2 and anti-oxidative treatments leads to an unprecedented improvement in glial-to-neuron conversion after traumatic brain injury in vivo, underscoring the relevance of these pathways in cellular reprograming irrespective of cell type in vitro and in vivo.

TL;DR: Improvements in transgenic mouse technology, rodent behavioral analyses, and the understanding of the neurogenesis process will allow us to refine the authors' conclusions and perform ever more specific experiments, and highlight work showing that adult-generated neurons are functionally important for the behavioral response to social stress.

TL;DR: A tripartite effector network activated by Pax6-BAF that programs neuronal fate is identified that drives neurogenesis and can convert postnatal glia into neurons.

TL;DR: A better understanding of the molecular logic for continuous adult neurogenesis provides important clues to develop strategies to manipulate endogenous stem cells for the purpose of repair.