C
Christophe Heinrich
Researcher at Claude Bernard University Lyon 1
Publications - 27
Citations - 2769
Christophe Heinrich is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Neurogenesis & Neural stem cell. The author has an hindex of 17, co-authored 25 publications receiving 2408 citations. Previous affiliations of Christophe Heinrich include Joseph Fourier University & University of Freiburg.
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Journal ArticleDOI
Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
Christophe Heinrich,Robert Blum,Susan Gascon,Giacomo Masserdotti,Pratibha Tripathi,Rodrigo Vega Sánchez,Steffen Tiedt,Timm Schroeder,Magdalena Götz,Magdalena Götz,Benedikt Berninger +10 more
TL;DR: Forced expression of single defined transcription factors can selectively and stably convert cultured astroglia into synapse-forming excitatory and inhibitory neurons.
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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
Swetlana Sirko,Gwendolyn Behrendt,Pia A Johansson,Pratibha Tripathi,Marcos R. Costa,Sarah Bek,Christophe Heinrich,Steffen Tiedt,Dilek Colak,Martin Dichgans,Isabel Rebekka Fischer,Nikolaus Plesnila,Matthias Staufenbiel,Christian Haass,Christian Haass,Marina Snapyan,Armen Saghatelyan,Li-Huei Tsai,Li-Huei Tsai,Andre Fischer,Kay Grobe,Leda Dimou,Magdalena Götz +22 more
TL;DR: These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
Journal ArticleDOI
Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus.
Christophe Heinrich,Naoki Nitta,Armin Flubacher,Martin Müller,Alexander Fahrner,Matthias Kirsch,Thomas M. Freiman,Fumio Suzuki,Antoine Depaulis,Michael Frotscher,Carola A. Haas +10 more
TL;DR: GCD does not result from an increased dentate neurogenesis associated with an abnormal migration of the newly generated granule cells, but reflects a displacement of mature granules cells, most likely caused by a local reelin deficiency.
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Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells
Marisa Karow,Rodrigo Vega Sánchez,Christian Schichor,Giacomo Masserdotti,Felipe Ortega,Christophe Heinrich,Susan Gascon,Muhammad Amir Khan,D. Chichung Lie,Arianna Dellavalle,Giulio Cossu,Roland Goldbrunner,Magdalena Götz,Benedikt Berninger,Benedikt Berninger +14 more
TL;DR: It is shown that cells from the adult human cerebral cortex expressing pericyte hallmarks can be reprogrammed into neuronal cells by retrovirus-mediated coexpression of the transcription factors Sox2 and Mash1, raising the possibility of functional conversion of endogenous cells in theadult human brain to induced neuronal fates.
Journal ArticleDOI
Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming
Susan Gascon,Elisa Murenu,Giacomo Masserdotti,Felipe Ortega,Felipe Ortega,Felipe Ortega,Gianluca Luigi Russo,David Petrik,Aditi Deshpande,Christophe Heinrich,Marisa Karow,Stephen P. Robertson,Timm Schroeder,Johannes Beckers,Martin Irmler,Carsten Berndt,José Pedro Friedmann Angeli,Marcus Conrad,Benedikt Berninger,Benedikt Berninger,Magdalena Götz +20 more
TL;DR: Co-expression of Bcl-2 and anti-oxidative treatments leads to an unprecedented improvement in glial-to-neuron conversion after traumatic brain injury in vivo, underscoring the relevance of these pathways in cellular reprograming irrespective of cell type in vitro and in vivo.