D
David S. Bredt
Researcher at Johnson & Johnson
Publications - 224
Citations - 63974
David S. Bredt is an academic researcher from Johnson & Johnson. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 107, co-authored 223 publications receiving 62332 citations. Previous affiliations of David S. Bredt include Johns Hopkins University & Georgetown University Medical Center.
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Journal ArticleDOI
PDZ protein interactions regulating glutamate receptor function and plasticity.
TL;DR: Neurotransmission occurs at synapses, specialized points of contact between presynaptic nerve terminals and postsynaptic neurons, a cytoskeletal web beneath the plasma membrane.
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AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase
Yan Qun Chen,Ming-Shang Kuo,Shuyu Li,Hai H. Bui,David A. Peake,Philip E. Sanders,Stefan Jon Thibodeaux,Shaoyou Chu,Yue-Wei Qian,Yang Zhao,David S. Bredt,David E. Moller,Robert J. Konrad,Anne P. Beigneux,Stephen G. Young,Guoqing Cao +15 more
TL;DR: It is shown that AGPAT6 is a microsomal glycerol-3-phosphate acyltransferase (GPAT), and a renaming of this enzyme GPAT4 is proposed.
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New Transmembrane AMPA Receptor Regulatory Protein Isoform, γ-7, Differentially Regulates AMPA Receptors
Akihiko Kato,Wei Zhou,Aaron D. Milstein,Mike D. Knierman,Edward R. Siuda,Joe E. Dotzlaf,Hong Yu,John E. Hale,Eric S. Nisenbaum,Roger A. Nicoll,David S. Bredt +10 more
TL;DR: In this paper, the role of the homologous γ-7 proteins was explored in the cerebellum of stargazer mice and showed that they can differentially influence AMPA receptors in cerebellar neurons.
Journal ArticleDOI
Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms
Dane M. Chetkovich,Robert C. Bunn,Sheng-Han Kuo,Yoshimi Kawasaki,Minoree Kohwi,David S. Bredt +5 more
TL;DR: Molecular and functional heterogeneity in synaptic PSD95 complexes are identified and critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering are revealed.
Journal ArticleDOI
cGMP-Dependent Protein Kinase in Dorsal Root Ganglion: Relationship with Nitric Oxide Synthase and Nociceptive Neurons
Yifang Qian,Daniel S. Chao,Daniel R. Santillano,Trudy L. Cornwell,Angus C. Nairn,Paul Greengard,Thomas M. Lincoln,David S. Bredt +7 more
TL;DR: It is demonstrated that cGMP-dependent protein kinase I (cGKI) occurs in the DRGs at levels comparable to that in cerebellum, the richest source of cGKI in the body.