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David S. Bredt
Researcher at Johnson & Johnson
Publications - 224
Citations - 63974
David S. Bredt is an academic researcher from Johnson & Johnson. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 107, co-authored 223 publications receiving 62332 citations. Previous affiliations of David S. Bredt include Johns Hopkins University & Georgetown University Medical Center.
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Journal ArticleDOI
TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
TL;DR: A striking heterogeneity in the effects of TARP subtypes on AMPAR deactivation and desensitization is reported, which is demonstrated controls the time course of synaptic transmission and suggests a variable TARP/AMPAR stoichiometry.
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Ultrastructural localization of nitric oxide synthase immunoreactivity in guinea-pig enteric neurons.
TL;DR: Results indicate that nitric oxide may regulate the activity of both myenteric neurons and smooth muscle, and leave unanswered the question of how Nitric oxide is stored and released.
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Characterization of MALS/Velis-1, -2, and -3: a Family of Mammalian LIN-7 Homologs Enriched at Brain Synapses in Association with the Postsynaptic Density-95/NMDA Receptor Postsynaptic Complex
TL;DR: This work suggests a role for MALS proteins in regulating recruitment of neurotransmitter receptors to the PSD, and identifies a family of small synaptic proteins containing little more than a single PDZ domain.
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Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease.
Bradley T. Hyman,Kristin Marzloff,Julia J. Wenniger,Ted M. Dawson,David S. Bredt,Solomon H. Snyder +5 more
TL;DR: It is shown that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.
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From molecules to mammals: what's NOS got to do with it?
Imran N. Mungrue,David S. Bredt,Duncan J. Stewart,Duncan J. Stewart,Mansoor Husain,Mansoor Husain +5 more
TL;DR: This review will outline the data gleaned from complementary knockout and transgenic over-expression models in mice, and focus on the interactions between NOS enzymes and pathophysiology of the vascular system.