D
David S. Bredt
Researcher at Johnson & Johnson
Publications - 224
Citations - 63974
David S. Bredt is an academic researcher from Johnson & Johnson. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 107, co-authored 223 publications receiving 62332 citations. Previous affiliations of David S. Bredt include Johns Hopkins University & Georgetown University Medical Center.
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Journal ArticleDOI
Molecular constituents of neuronal AMPA receptors
Yuko Fukata,Anastassios V. Tzingounis,Jonathan C. Trinidad,Masaki Fukata,Alma L. Burlingame,Roger A. Nicoll,David S. Bredt +6 more
TL;DR: TARPs are established as the auxiliary components of neuronal AMPARs by immunoprecipitation from brain extracts, and stargazin-like transmembrane AMPAR regulatory proteins copurified with neuronal AM PARs, but there is negligible binding to GRIP, PICK, NSF, or SAP-97.
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Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95.
TL;DR: The solution structure of PSD-95 PDZ2 was determined to high resolution by NMR spectroscopy and it appears that the loop adopts a pre-aligned conformation for the PDZ domain to interact with its targets.
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Regulation of Dendritic Branching and Filopodia Formation in Hippocampal Neurons by Specific Acylated Protein Motifs
TL;DR: It is demonstrated that select dually lipidated protein motifs trigger changes in the development and growth of neuronal processes.
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Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting
Bonnie L. Firestein,Jay E. Brenman,Chiye Aoki,Ana María Sánchez-Pérez,Alaa El-Husseini,David S. Bredt +5 more
TL;DR: Overexpression of cypin in hippocampal neurons specifically perturbs postsynaptic trafficking of PSD-95 and SAP-102, an effect not produced by overeexpression of other PDZ ligands.
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Nitric oxide synthase-immunoreactive nerve fibers in dog cerebral and peripheral arteries
TL;DR: It is concluded that perivascular nerves containing NOS are crucial in eliciting the neurally induced, NO-mediated arterial relaxation.