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David S. Bredt
Researcher at Johnson & Johnson
Publications - 224
Citations - 63974
David S. Bredt is an academic researcher from Johnson & Johnson. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 107, co-authored 223 publications receiving 62332 citations. Previous affiliations of David S. Bredt include Johns Hopkins University & Georgetown University Medical Center.
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Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions
TL;DR: Diverse roles in tissue development, differentiation, and physiology are explained by recent biochemical and structural analyses of MAGUKs, which demonstrate their capacity to assemble well--efined--yet adaptable--protein complexes at cellular junctions.
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Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: The cloning, characterization and functional expression of cDNAs encoding rat brain nitric oxide synthase (NOS) are described, which is responsible for intracellular synthesis of NO from arginine, and the sequence reveals putative sites for interaction with calmodulin and for phosphorylation by cyclic AMP-dependent protein kinase.
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Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.
Guillermo M. Elias,Lars Funke,Lars Funke,Valentin Stein,Seth G. N. Grant,David S. Bredt,Roger A. Nicoll +6 more
TL;DR: A PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system is established.
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Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries.
Kazuhiko Nozaki,Michael A. Moskowitz,Kenneth I. Maynard,Naoki Koketsu,Ted M. Dawson,David S. Bredt,Solomon H. Snyder +6 more
TL;DR: The coexistence of NOS and VIP within sphenopalatine ganglion cells raises the possibility that two vasodilatory agents, one, a highly diffusable short-lived, low-molecular-weight molecule, and the other, a polar 28 amino acid-containing peptide, may serve as coneuromediators within the cerebral circulation.
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Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: The transient expression of neuronal NOS may reflect a role in developmental processes such as programmed cell death, and in other neuronal sites NOS staining appears after cell bodies cease dividing and cells extend processes, and the staining persists in adult life.