David S. Gilmour

TL;DR: A high-resolution reference map of H2A.Z and bulk nucleosome locations across the genome of the fly Drosophila melanogaster is produced and that from the yeast Saccharomyces cerevisiae is compared.

TL;DR: It is hypothesized that RNA polymerase II has access to, and a high affinity for, the promoter region of this gene before induction, and this poised RNA polymerases II may be critical in the mechanism of transcription activation.

TL;DR: It is proposed that NELF and DSIF cause polymerase to pause in the promoter proximal region of hsp70, and the transcriptional activator, HSF, might cause NELF to dissociate from the elongation complex.

TL;DR: The data reveal that the presence of stalled Pol II at this latter group of genes enhances gene expression by maintaining a permissive chromatin architecture around the promoter-proximal region, and that loss of Pol II stalling at these promoters is accompanied by a significant increase in nucleosome occupancy and a decrease in histone H3 Lys 4 trimethylation.

TL;DR: The in vivo data of RNA polymerase on the leucine operon of Salmonella in wild-type, attenuator mutant, and promoter mutant strains are in complete agreement with the predictions of the attenuation model of regulation.