David S. Zuzga

TL;DR: Systemic administration of [Ser(2)]exendin(1–9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons and represents a promising new target for both cognitive-enhancing and neuroprotective agents.

TL;DR: It is shown that hippocampal expression of vascular endothelial growth factor (VEGF) is increased by both an enriched environment and performance in a spatial maze, supporting a model in which VEGF, acting through KDR, mediates the effect of the environment on neurogenesis and cognition.

TL;DR: Using adeno-associated viral vector–mediated somatic cell gene transfer, glutamic acid decarboxylase (GAD), the enzyme that catalyzes synthesis of the neurotransmitter GABA, is expressed in excitatory glutamatergic neurons of the STN in rats, resulting in strong neuroprotection of nigral dopamine neurons and rescue of the parkinsonian behavioral phenotype.

TL;DR: Observations reveal that MMP-9 produced by human colon cancer, rather than stromal, cells is central to processes underlying metastasis and underscores the previously unrecognized potential of specifically targeting tumor cell M MP-9 in interventional strategies to reduce mortality from metastatic colorectal cancer.

TL;DR: In the intestine, guanylyl cyclase C and its paracrine ligands organize and regulate the homeostatic integrity of the crypt–villus axis, forming a hormonal tumor suppressor signaling sequence, whose dysfunction defines the initiation of neoplastic transformation and creates a permissive niche for tumor progression.