J
Jeremy S. Francis
Researcher at Rowan University
Publications - 22
Citations - 2003
Jeremy S. Francis is an academic researcher from Rowan University. The author has contributed to research in topics: Aspartoacylase & Canavan disease. The author has an hindex of 16, co-authored 22 publications receiving 1815 citations. Previous affiliations of Jeremy S. Francis include Rutgers University & University of Auckland.
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Journal ArticleDOI
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Matthew J. During,Lei Cao,David S. Zuzga,Jeremy S. Francis,Helen L. Fitzsimons,Xiangyang Jiao,Ross J. Bland,Matthias Klugmann,William A. Banks,Daniel J. Drucker,Colin N. Haile +10 more
TL;DR: Systemic administration of [Ser(2)]exendin(1–9) in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons and represents a promising new target for both cognitive-enhancing and neuroprotective agents.
Journal ArticleDOI
Immune responses to AAV in a phase I study for Canavan disease
Scott W. McPhee,Christopher G. Janson,Christopher G. Janson,Chengwen Li,Richard Jude Samulski,Angelique S. Camp,Jeremy S. Francis,David Shera,L. Lioutermann,M. Feely,Andrew Freese,Paola Leone +11 more
TL;DR: This study represents the first use of a viral vector in an attempt to ameliorate a neurodegenerative disorder, and rAAV‐ASPA has been developed for gene delivery to the central nervous system for Canavan disease.
Journal ArticleDOI
Long-Term Follow-Up After Gene Therapy for Canavan Disease
Paola Leone,David Shera,Scott W.J. McPhee,Jeremy S. Francis,Edwin H. Kolodny,Larissa T. Bilaniuk,Dah Jyuu Wang,Mitra Assadi,Olga Goldfarb,H. Warren Goldman,Andrew Freese,Deborah Young,Matthew J. During,Matthew J. During,R. Jude Samulski,Christopher G. Janson +15 more
TL;DR: The investigators found that gene therapy was safe and led to a decrease in N-acetyl-aspartate in the brain, together with decreased seizure frequency and clinical stabilization, and a lack of long-term adverse events related to the AAV2 vector.
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Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
Emmanuel L. Gautier,Stoyan Ivanov,Jesse W. Williams,Stanley Ching-Cheng Huang,Genevieve Marcelin,Keke C. Fairfax,Peter L. Wang,Jeremy S. Francis,Paola Leone,David B. Wilson,Maxim N. Artyomov,Edward J. Pearce,Gwendalyn J. Randolph +12 more
TL;DR: Gata6 regulates differentiation, metabolism and survival of peritoneal macrophages in mice and appears to have an important role in cell differentiation and survival.
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Development of new inbred transgenic strains of rats with LacZ or GFP.
Hirokazu Inoue,Ichiro Ohsawa,Takashi Murakami,Atsushi Kimura,Yoji Hakamata,Yuki Sato,Takashi Kaneko,Masafumi Takahashi,Takashi Okada,Keiya Ozawa,Jeremy S. Francis,Paola Leone,Eiji Kobayashi +12 more
TL;DR: New inbred transgenic rat strains with lacZ and GFP based on the transgenic (Tg) animal technique in rats may provide great benefits for the elucidation of the cellular process of regenerative medicine, including cell and tissue transplantation.