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David Sept

Researcher at University of Michigan

Publications -  117
Citations -  12535

David Sept is an academic researcher from University of Michigan. The author has contributed to research in topics: Actin cytoskeleton & Microtubule. The author has an hindex of 41, co-authored 113 publications receiving 11326 citations. Previous affiliations of David Sept include University of California, San Diego & Washington University in St. Louis.

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Electrostatics of nanosystems: Application to microtubules and the ribosome

TL;DR: The application of numerical methods are presented to enable the trivially parallel solution of the Poisson-Boltzmann equation for supramolecular structures that are orders of magnitude larger in size.
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An electric-eel-inspired soft power source from stacked hydrogels.

TL;DR: An electric-eel-inspired power concept that uses gradients of ions between miniature polyacrylamide hydrogel compartments bounded by a repeating sequence of cation- and anion-selectivehydrogel membranes suggests that artificial electric organs could be used to power next-generation implant materials such as pacemakers, implantable sensors, or prosthetic devices in hybrids of living and non-living systems.
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Thermodynamics and kinetics of actin filament nucleation.

TL;DR: The results indicate that the trimer is the size of the critical nucleus, and the rate constants produce polymerization plots that agree very well with experimental results over a range of actin monomer concentrations.
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Capping protein regulators fine-tune actin assembly dynamics

TL;DR: A diverse and unrelated group of proteins interact with CP through a conserved 'capping protein interaction' (CPI) motif, and these proteins recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.