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David Sept
Researcher at University of Michigan
Publications - 117
Citations - 12535
David Sept is an academic researcher from University of Michigan. The author has contributed to research in topics: Actin cytoskeleton & Microtubule. The author has an hindex of 41, co-authored 113 publications receiving 11326 citations. Previous affiliations of David Sept include University of California, San Diego & Washington University in St. Louis.
Papers
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Journal ArticleDOI
Electrostatics of nanosystems: Application to microtubules and the ribosome
TL;DR: The application of numerical methods are presented to enable the trivially parallel solution of the Poisson-Boltzmann equation for supramolecular structures that are orders of magnitude larger in size.
Journal ArticleDOI
Real-time shape approximation and fingerprinting of single proteins using a nanopore.
Erik Yusko,Brandon R. Bruhn,Olivia M. Eggenberger,Olivia M. Eggenberger,Jared Houghtaling,Jared Houghtaling,Ryan Rollings,Nathan Walsh,Santoshi Nandivada,Mariya A. Pindrus,Adam R. Hall,David Sept,Jiali Li,Devendra S. Kalonia,Michael Mayer,Michael Mayer +15 more
TL;DR: The zeptolitre sensing volume of bilayer-coated solid-state nanopores can be used to determine the approximate shape, volume, charge, rotational diffusion coefficient and dipole moment of individual proteins.
Journal ArticleDOI
An electric-eel-inspired soft power source from stacked hydrogels.
Thomas Schroeder,Thomas Schroeder,Anirvan Guha,Aaron Lamoureux,Gloria VanRenterghem,David Sept,Max Shtein,Jerry Yang,Michael Mayer,Michael Mayer +9 more
TL;DR: An electric-eel-inspired power concept that uses gradients of ions between miniature polyacrylamide hydrogel compartments bounded by a repeating sequence of cation- and anion-selectivehydrogel membranes suggests that artificial electric organs could be used to power next-generation implant materials such as pacemakers, implantable sensors, or prosthetic devices in hybrids of living and non-living systems.
Journal ArticleDOI
Thermodynamics and kinetics of actin filament nucleation.
David Sept,J. Andrew McCammon +1 more
TL;DR: The results indicate that the trimer is the size of the critical nucleus, and the rate constants produce polymerization plots that agree very well with experimental results over a range of actin monomer concentrations.
Journal ArticleDOI
Capping protein regulators fine-tune actin assembly dynamics
TL;DR: A diverse and unrelated group of proteins interact with CP through a conserved 'capping protein interaction' (CPI) motif, and these proteins recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.