Journal ArticleDOI
Dealing With Energy Demand: The AMP-activated Protein Kinase
Bruce E. Kemp,Ken I. Mitchelhill,David Stapleton,Belinda J. Michell,Zhi-Ping Chen,Lee A. Witters +5 more
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TLDR
The AMP-activated protein kinase yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation, and has diverse roles that extend from energy metabolism through to transcriptional control in mammals.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1999-01-01. It has received 522 citations till now. The article focuses on the topics: AMPK & Mitogen-activated protein kinase kinase.read more
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Upstream and downstream of mTOR
Nissim Hay,Nahum Sonenberg +1 more
TL;DR: Both the upstream components of the signaling pathway(s) that activates mammalian TOR (mTOR) and the downstream targets that affect protein synthesis are described.
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The AMP-activated protein kinase cascade-a unifying system for energy control
TL;DR: AMP-activated protein kinase could provide a link in human diseases of which the underlying cause is due to defects in energy metabolism, and might play a part in protecting the body from metabolic diseases such as type 2 diabetes and obesity.
Journal ArticleDOI
Mitochondrial membrane potential.
Ljubava D. Zorova,Vasily A. Popkov,Egor Y. Plotnikov,Denis N. Silachev,Irina B. Pevzner,S. S. Jankauskas,V. A. Babenko,S. D. Zorov,Anastasia V. Balakireva,Magdalena Juhaszova,Steven J. Sollott,Dmitry B. Zorov,Dmitry B. Zorov +12 more
TL;DR: Additional potential mechanisms for which ΔΨm is essential for maintenance of cellular health and viability are proposed and recommendations how to accurately measure ΔΩm in a cell are provided and potential sources of artifacts are discussed.
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Sugar Sensing and Signaling in Plants
TL;DR: In addition to their essential roles as substrates in carbon and energy metabolism and in polymer biosynthesis, sugars have important hormone-like functions as primary messengers in signal transduction.
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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
Haihong Zong,Jian Ming Ren,Jian Ming Ren,Lawrence H. Young,Marc Pypaert,James Mu,Morris J. Birnbaum,Gerald I. Shulman +7 more
TL;DR: By sensing the energy status of the muscle cell, AMPK is a critical regulator involved in initiating mitochondrial biogenesis and abrogated GPA-induced increases in the expression of peroxisome proliferator-activated receptor γ coactivator 1α and calcium/calmodulin-dependent protein kinase IV.
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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
TL;DR: AMP-activated protein kinase and SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.
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The AMP‐Activated Protein Kinase
D. Grahame Hardie,David Carling +1 more
TL;DR: The central hypothesis is that the AMP-activated protein kinase cascade appears to be an ancient system which evolved to protect cells against the effects of nutritional or environmental stress, and protects the cell by switching off ATP-consuming pathways and switching on alternative pathways for ATP generation.
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Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase
Simon A. Hawley,Matthew Davison,Angela Woods,Stephen P. Davies,Raj K. Beri,David Carling,D. Grahame Hardie +6 more
TL;DR: This finding is consistent with the recent report that the AMP-activated protein kinase kinase can slowly phosphorylate and activate calmodulin-dependentprotein kinase I, at least in vitro.
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5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
TL;DR: AICAR provides direct evidence that the inhibition by AMPK of activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase also operates in intact cells, and should be a useful tool for identifying new target pathways and processes regulated by theprotein kinase cascade.
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5‐Aminoimidazole‐4‐Carboxamide Ribonucleoside
TL;DR: AICAR provides direct evidence that the inhibition by AMPK of activation of hormone-sensitive lipase by cyclic-AMP-dependent protein kinase also operates in intact cells, and should be a useful tool for identifying new target pathways and processes regulated by theprotein kinase cascade.