David W. Dales

TL;DR: Evidence is provided that PCP signaling can act in a context dependent manner to promote breast cancer progression and is expressed highest in 21MT-1 cells (invasive mammary carcinoma) and lowest in 21PT and 21NT cells.

TL;DR: The crystal structure of the N‐terminal G domain of SHBG in complex with 5α‐dihydrotestosterone at 1.55 Å resolution reveals both the architecture of the steroid‐binding site and the quaternary structure ofThe dimer, and shows that G domains have jellyroll topology and are structurally related to pentraxin.

TL;DR: Results demonstrate that 11 beta-HSD gene expression in sheep is regulated in a tissue-specific and developmentally programmed manner.

TL;DR: This study tested the hypothesis that re‐expression of OPN in metastasis‐suppressed 435/BRMS1 cells would reverse metastasis suppression and confer protection from stress‐induced apoptosis, and suggested that OPN downregulation by BRMS1 may be responsible, at least in part, for BR MS1‐mediated metastasis suppressed by sensitizing cancer cells to stress induced apoptosis.

TL;DR: Novel findings demonstrate that BR MS1 is a potent suppressor of metastasis in multiple organs, and identify two steps in the metastatic process that are sensitive to inhibition by BRMS1.