D
Dawn Waterworth
Researcher at GlaxoSmithKline
Publications - 19
Citations - 2524
Dawn Waterworth is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Polycystic ovary & Genome-wide association study. The author has an hindex of 14, co-authored 19 publications receiving 2294 citations. Previous affiliations of Dawn Waterworth include Imperial College London.
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Journal ArticleDOI
Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease
Paul Elliott,John C. Chambers,Weihua Zhang,Robert Clarke,J C Hopewell,John F. Peden,Jeanette Erdmann,Peter S. Braund,James C. Engert,Derrick A Bennett,Lachlan J. M. Coin,Deborah Ashby,Ioanna Tzoulaki,Ian J. Brown,Shahrul Mt-Isa,Mark I. McCarthy,Leena Peltonen,Nelson B. Freimer,Martin Farrall,Aimo Ruokonen,Anders Hamsten,Noha Lim,Philippe Froguel,Dawn Waterworth,Peter Vollenweider,Gerard Waeber,Marjo-Riitta Järvelin,Vincent Mooser,James Scott,Alistair S. Hall,Heribert Schunkert,Sonia S. Anand,Rory Collins,Nilesh J. Samani,Hugh Watkins,Jaspal S. Kooner +35 more
TL;DR: In this article, the most closely associated single-nucleotide polymorphism (SNP) in the CRP locus and published data on other CRP variants involving a total of 28,112 cases and 100,823 controls, were investigated to investigate the association of these variants with coronary heart disease.
Journal ArticleDOI
Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17
A. H. Carey,Dawn Waterworth,Kirty Patel,Davinia White,Julie Little,Patricia Novelli,Stephen Franks,Robert Williamson +7 more
TL;DR: Variation in the A2 allele of the CYP17 gene is a significant factor modifying the expression of PCO/MPB in families where it has been demonstrated to segregate as a single gene disorder, but it is excluded as the primary genetic defect.
Journal ArticleDOI
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
Dawn Waterworth,Simon T. Bennett,Neda Gharani,Mark I. McCarthy,Stephen Hague,Sari Batty,Gerard S. Conway,Davinia White,John A. Todd,Stephen Franks,Robert Williamson +10 more
TL;DR: Mapping of susceptibility to PCOS to the INS VNTR implies that PCOS is due, in part, to an inherited alteration in insulin production, which suggests a mechanistic link between type 2 diabetes and PCOS, which is a risk factor for diabetes later in life.
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Association of the Steroid Synthesis Gene Cyp11a with Polycystic Ovary Syndrome and Hyperandrogenism
Neda Gharani,Dawn Waterworth,Sari Batty,Davinia White,Carole Gilling-Smith,Gerard S. Conway,Mark I. McCarthy,Stephen Franks,Robert Williamson,Robert Williamson +9 more
TL;DR: The data demonstrate that variation in CYP11a may play an important role in the aetiology of hyperandrogenaemia which is a common characteristic of polycystic ovary syndrome.
Journal ArticleDOI
The genetic basis of polycystic ovary syndrome.
Stephen Franks,Neda Gharani,Dawn Waterworth,Sari Batty,Davinia White,Robert Williamson,Mark I. McCarthy +6 more
TL;DR: The results of recent studies support the concept of an oligogenic disorder in which genes affecting metabolic pathways in glucose homeostasis and steroid biosynthesis are both involved and support the proposed interaction of a small number of key genes with environmental, particularly nutritional, factors.