Journal ArticleDOI
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
Dawn Waterworth,Simon T. Bennett,Neda Gharani,Mark I. McCarthy,Stephen Hague,Sari Batty,Gerard S. Conway,Davinia White,John A. Todd,Stephen Franks,Robert Williamson +10 more
TLDR
Mapping of susceptibility to PCOS to the INS VNTR implies that PCOS is due, in part, to an inherited alteration in insulin production, which suggests a mechanistic link between type 2 diabetes and PCOS, which is a risk factor for diabetes later in life.About:
This article is published in The Lancet.The article was published on 1997-04-05. It has received 320 citations till now. The article focuses on the topics: Polycystic ovary & Male-pattern baldness.read more
Citations
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Journal ArticleDOI
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.
TL;DR: Since PCOS usually has a menarchal age of onset, this makes it a particularly appropriate disorder in which to examine the ontogeny of defects in carbohydrate metabolism and for ascertaining large three-generation kindreds for positional cloning studies to identify NIDDM genes.
Journal ArticleDOI
Polycystic ovary syndrome.
TL;DR: It is now clear that the range of presenting symptoms of women with polycystic ovaries includes not only nonhirsute women with oligomenorrhoea or amenorrhOEa but also hirsute subjects with regular, ovulatory cycles.
Journal ArticleDOI
Polycystic ovary syndrome.
TL;DR: This review addresses current concepts regarding the diagnosis, cause, and treatment of the polycystic ovary syndrome.
Journal ArticleDOI
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
TL;DR: In this paper, the authors summarized the state of the science since the last review in the Endocrine Reviews in 1997, and concluded that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity.
Journal ArticleDOI
Polycystic ovary syndrome.
Ricardo Azziz,Enrico Carmina,Zi-Jiang Chen,Andrea Dunaif,Joop S.E. Laven,Richard S. Legro,Daria Lizneva,Daria Lizneva,Barbara Natterson-Horowtiz,Helena J. Teede,Bulent O. Yildiz +10 more
TL;DR: PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss, and the risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased.
References
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Journal ArticleDOI
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.
C. N. Hales,David J.P. Barker +1 more
TL;DR: It is proposed that one of the major long-term consequences of inadequate early nutrition is impaired development of the endocrine pancreas and a greatly increased susceptibility to the development of Type 2 diabetes.
Journal Article
Parametric and nonparametric linkage analysis: a unified multipoint approach.
TL;DR: It is shown that NPL is robust to uncertainty about mode of inheritance, is much more powerful than commonly used nonparametric methods, and loses little power relative to parametric linkage analysis, and appears to be the method of choice for pedigree studies of complex traits.
Journal ArticleDOI
Polycystic ovary syndrome.
TL;DR: It is now clear that the range of presenting symptoms of women with polycystic ovaries includes not only nonhirsute women with oligomenorrhoea or amenorrhOEa but also hirsute subjects with regular, ovulatory cycles.
Journal ArticleDOI
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
TL;DR: PCO women have significant insulin resistance that is independent of obesity, changes in body composition, and impairment of glucose tolerance, and PCO is associated with a unique disorder of insulin action.
Journal ArticleDOI
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism
TL;DR: It is shown that polycystic ovaries, as defined by pelvic ultrasound, are very common in anovulatory women and are not necessarily associated with hirsutism or a raised serum luteinising hormone concentration.