Dawna D. Armstrong

TL;DR: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults.

TL;DR: The proposed international consensus classification of hippocampal neuronal cell loss will aid in the characterization of specific clinicopathologic syndromes, and explore variability in imaging and electrophysiology findings, and in postsurgical seizure control.

TL;DR: The available data suggest that the neuropathology of Rett syndrome can be summarized as follows: the Rett brain is small for the age and the height of the patient; it does not become progressively smaller over three to four decades; it has small dendritic trees in pyramidal neurons of layers III and V in selected lobes.

TL;DR: The role of the methyl-CpG binding protein 2 gene (MECP2) in the pathogenesis of Rett syndrome has been extensively investigated in animal models as discussed by the authors.

TL;DR: Interactions between the reelin signaling pathway and Lis1 in brain development are investigated and Dab1 and Lis 1 bound in a reelin-induced phosphorylation-dependent manner, indicating genetic and biochemical interaction between the self-reinforcing pathways.