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Richard S. Lemons
Researcher at University of Utah
Publications - 58
Citations - 3130
Richard S. Lemons is an academic researcher from University of Utah. The author has contributed to research in topics: Gene & Leukemia. The author has an hindex of 25, co-authored 56 publications receiving 2988 citations. Previous affiliations of Richard S. Lemons include University of Chicago & Washington University in St. Louis.
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Journal ArticleDOI
A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
Deborah J. Good,Peter J. Polverini,F Rastinejad,M M Le Beau,Richard S. Lemons,William A. Frazier,Noel P. Bouck +6 more
TL;DR: A secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in hamster cells has been found to be similar to a fragment of the platelet and matrix protein thrombospondin, which demonstrates a function for the ubiquitous adhesive glycoprotein thromBosponin that is likely to be important in the normal physiological down-regulation of neovascularization.
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Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.
Mark L. Watson,Stephen F. Kingsmore,Geoffrey I. Johnston,Mark H. Siegelman,Michelle M. Le Beau,Richard S. Lemons,N S Bora,Thad A. Howard,Irving L. Weissman,Rodger P. McEver,Michael F. Seldin +10 more
TL;DR: The location of these genes on mouse and human chromosome 1 is consistent with a close evolutionary relationship to the complement receptor-related genes, which also are positioned on the same chromosomes in both species and with which these genes share a region of sequence homology.
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Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial
John D. Grainger,Franco Locatelli,Thirachit Chotsampancharoen,Elena K. Donyush,Bunchoo Pongtanakul,Patcharee Komvilaisak,Darintr Sosothikul,Guillermo Drelichman,Nongnuch Sirachainan,Susanne Holzhauer,Vladimir Lebedev,Richard S. Lemons,Dagmar Pospisilova,Ugo Ramenghi,James B. Bussel,Kalpana Bakshi,Malini Iyengar,Geoffrey W. Chan,Karen Chagin,Dickens Theodore,Lisa M Marcello,Christine K Bailey +21 more
TL;DR: The primary outcome was the proportion of patients achieving platelet counts of at least 50 × 10(9) per L in the absence of rescue therapy for 6 or more weeks from weeks 5 to 12 of the double-blind period.
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Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q).
TL;DR: The findings that each IL-4 and IL-5 genes was deleted in the 5q- chromosome suggest that loss of function of one or more of these genes may play an important role in the pathogenesis of hematologic disorders associated with a del(5q).
Journal ArticleDOI
Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders
Mark J. Pettenati,M M Le Beau,Richard S. Lemons,E A Shima,E S Kawasaki,Richard A. Larson,Charles J. Sherr,Manuel O. Diaz,Janet Rowley +8 more
TL;DR: A small segment of chromosome 5 contains GM-CSF, CSF, and FMS, which encodes the CSF-1 receptor, in that order from the centromere; this cluster of genes may be involved in the altered hematopoiesis associated with a deletion of 5q.