John E.A. Common

TL;DR: The first recessive human mutation, 7901delG, in the desmoplakin gene is described which causes a generalized striate keratoderma particularly affecting the palmoplantar epidermis, woolly hair and a dilated left ventricular cardiomyopathy and a number of the patients with this syndromic disorder suffer heart failure in their teenage years, resulting in early morbidity.

TL;DR: A revised and expanded database on human intermediate filament proteins, a major component of the eukaryotic cytoskeleton, it is anticipated that the HIFD will provide a useful resource to study human genome variations for basic scientists, clinicians, and students alike.

TL;DR: Findings provide insights into how the skin microbial community, skin surface microenvironment and immune system cross-modulate each other, escalating the destructive feedback cycle between them that leads to AD flare.

TL;DR: Both LMNB1 depletion and overexpression inhibit proliferation, but onlyLMNB1 overexpressed induces senescence.

TL;DR: Observations indicate that cell lines derived from HNSCC contain cells with stem cell properties and that such cell lines may provide experimental systems relevant to the behaviour of stem cells present in the tumours of origin and to their responses to therapy.