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Deepak Nagrath
Researcher at University of Michigan
Publications - 86
Citations - 5162
Deepak Nagrath is an academic researcher from University of Michigan. The author has contributed to research in topics: Cancer & Tumor microenvironment. The author has an hindex of 33, co-authored 70 publications receiving 3726 citations. Previous affiliations of Deepak Nagrath include Rice University & Rensselaer Polytechnic Institute.
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Journal ArticleDOI
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Hongyun Zhao,Lifeng Yang,Joelle Baddour,Abhinav Achreja,Vincent Bernard,Tyler J. Moss,Juan C. Marini,Thavisha Tudawe,Elena G. Seviour,F. Anthony San Lucas,Héctor M. Alvarez,Sonal Gupta,Sourindra Maiti,Laurence J.N. Cooper,Donna M. Peehl,Prahlad T. Ram,Anirban Maitra,Deepak Nagrath +17 more
TL;DR: It is demonstrated that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells, and that CAF-derived exosome (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells.
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Glutaminolysis: A Hallmark of Cancer Metabolism
TL;DR: The mechanism of glutamine's regulation of tumor proliferation, metastasis, and global methylation is described and it is highlighted that clinical application of in vivo assessment of glutamines metabolism is critical for identifying new ways to treat patients through glutamine-based metabolic therapy.
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Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Lifeng Yang,Abhinav Achreja,Tsz-Lun Yeung,Lingegowda S. Mangala,Dahai Jiang,Cecil Han,Joelle Baddour,Juan C. Marini,Joseph Ni,Ryuichi Nakahara,Stephen Wahlig,Lisa Chiba,Sun Hye Kim,Joshua Morse,Sunila Pradeep,Archana S. Nagaraja,Monika Haemmerle,Noh Kyunghee,Mathew Derichsweiler,Thomas Plackemeier,Imelda Mercado-Uribe,Gabriel Lopez-Berestein,Tyler J. Moss,Prahlad T. Ram,Jinsong Liu,Xiongbin Lu,Samuel C. Mok,Anil K. Sood,Deepak Nagrath +28 more
TL;DR: This work identifies a previously unrecognized mechanism whereby metabolism of reactive stromal cells is reprogrammed through an upregulated glutamine anabolic pathway and presents a synthetic lethal approach to target tumor stroma and cancer cells simultaneously for desirable therapeutic outcomes.
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The role of stromal cancer-associated fibroblasts in pancreatic cancer
TL;DR: This review summarizes the most recent progress made in understanding stromal formation; its contribution to tumor proliferation, invasion, and metastasis; its role in chemoresistance; and potential therapeutic strategies on the horizon.
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Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Lifeng Yang,Tyler J. Moss,Lingegowda S. Mangala,Juan C. Marini,Hongyun Zhao,Stephen Wahlig,Stephen Wahlig,Guillermo N. Armaiz-Pena,Dahai Jiang,Abhinav Achreja,Julia Win,Rajesha Roopaimoole,Cristian Rodriguez-Aguayo,Imelda Mercado-Uribe,Gabriel Lopez-Berestein,Jinsong Liu,Takashi Tsukamoto,Anil K. Sood,Prahlad T. Ram,Deepak Nagrath +19 more
TL;DR: It is found that low‐invasive ovarian cancer (OVCA) cells are glutamine independent, whereas high-invasive OVCA cells are markedly glutamine dependent, and the ratio of gene expression associated with glutamine anabolism versus catabolism has emerged as a novel biomarker for patient prognosis.