D
Dahai Jiang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 26
Citations - 1171
Dahai Jiang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 16 publications receiving 895 citations. Previous affiliations of Dahai Jiang include University of Texas Health Science Center at Houston & University of Texas at Austin.
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Journal ArticleDOI
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Lifeng Yang,Abhinav Achreja,Tsz-Lun Yeung,Lingegowda S. Mangala,Dahai Jiang,Cecil Han,Joelle Baddour,Juan C. Marini,Joseph Ni,Ryuichi Nakahara,Stephen Wahlig,Lisa Chiba,Sun Hye Kim,Joshua Morse,Sunila Pradeep,Archana S. Nagaraja,Monika Haemmerle,Noh Kyunghee,Mathew Derichsweiler,Thomas Plackemeier,Imelda Mercado-Uribe,Gabriel Lopez-Berestein,Tyler J. Moss,Prahlad T. Ram,Jinsong Liu,Xiongbin Lu,Samuel C. Mok,Anil K. Sood,Deepak Nagrath +28 more
TL;DR: This work identifies a previously unrecognized mechanism whereby metabolism of reactive stromal cells is reprogrammed through an upregulated glutamine anabolic pathway and presents a synthetic lethal approach to target tumor stroma and cancer cells simultaneously for desirable therapeutic outcomes.
Journal ArticleDOI
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Lifeng Yang,Tyler J. Moss,Lingegowda S. Mangala,Juan C. Marini,Hongyun Zhao,Stephen Wahlig,Stephen Wahlig,Guillermo N. Armaiz-Pena,Dahai Jiang,Abhinav Achreja,Julia Win,Rajesha Roopaimoole,Cristian Rodriguez-Aguayo,Imelda Mercado-Uribe,Gabriel Lopez-Berestein,Jinsong Liu,Takashi Tsukamoto,Anil K. Sood,Prahlad T. Ram,Deepak Nagrath +19 more
TL;DR: It is found that low‐invasive ovarian cancer (OVCA) cells are glutamine independent, whereas high-invasive OVCA cells are markedly glutamine dependent, and the ratio of gene expression associated with glutamine anabolism versus catabolism has emerged as a novel biomarker for patient prognosis.
Journal ArticleDOI
TP53 loss creates therapeutic vulnerability in colorectal cancer
Yunhua Liu,Xinna Zhang,Cecil Han,Guohui Wan,Xingxu Huang,Cristina Ivan,Dahai Jiang,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Pulivarthi H. Rao,Dipen M. Maru,Andreas Pahl,Xiaoming He,Anil K. Sood,Lee M. Ellis,Jan Anderl,Xiongbin Lu +16 more
TL;DR: It is demonstrated that low doses of α-amanitin-conjugated anti-epithelial cell adhesion molecule (EpCAM) antibody lead to complete tumour regression in mouse models of human colorectal cancer with hemizygous deletion of POLR2A.
Journal ArticleDOI
Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche.
Fabrizio Miranda,David Mannion,Shujuan Liu,Yiyan Zheng,Lingegowda S. Mangala,Clara Redondo,Sandra Herrero-Gonzalez,Ruoyan Xu,Charlotte Taylor,Donatien Fotso Chedom,Mohammad KaramiNejadRanjbar,Ashwag Albukhari,Ashwag Albukhari,Dahai Jiang,Sunila Pradeep,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Eidarus Salah,Kamal R. Abdul Azeez,Jonathan M. Elkins,Leticia Campo,Kevin A. Myers,Daniel Klotz,Serena Bivona,Sunanda Dhar,Robert C. Bast,Hideyuki Saya,Hwan Geun Choi,Nathanael S. Gray,Roman Fischer,Benedikt M. Kessler,Christopher Yau,Anil K. Sood,Takeshi Motohara,Stefan Knapp,Stefan Knapp,Ahmed Ashour Ahmed +36 more
TL;DR: This work shows that salt-inducible kinase 2 (SIK2) is overexpressed in adipocyte-rich metastatic deposits compared with ovarian primary lesions, and identifies SIK2 at the apex of the adipocytes-induced signaling cascades in cancer cells and makes a compelling case for targeting Sik2 for therapy in ovarian cancer.
Journal ArticleDOI
MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels
Yunqi Lu,Zhongyi Hu,Lingegowda S. Mangala,Zachary E. Stine,Xiaowen Hu,Dahai Jiang,Yan Xiang,Youyou Zhang,Sunila Pradeep,Cristian Rodriguez-Aguayo,Gabriel Lopez-Berestein,Angelo M. DeMarzo,Anil K. Sood,Lin Zhang,Chi V. Dang,Chi V. Dang,Chi V. Dang +16 more
TL;DR: It is reported that MYC stimulates the transcription of DANCR, a long noncoding RNA (lncRNA) that is widely overexpressed in human cancer that was identified through its overexpression in a transgenic model of MYC-induced lymphoma.