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Deepak Reyon
Researcher at Harvard University
Publications - 53
Citations - 17227
Deepak Reyon is an academic researcher from Harvard University. The author has contributed to research in topics: Genome editing & Transcription activator-like effector nuclease. The author has an hindex of 33, co-authored 51 publications receiving 15306 citations. Previous affiliations of Deepak Reyon include Iowa State University & University of Minnesota.
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Journal ArticleDOI
Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.
Evisa Gjini,Chang-Bin Jing,Ashley T. Nguyen,Deepak Reyon,Emma Gans,Michiel Kesarsing,Joshua Peterson,Olga Pozdnyakova,Scott J. Rodig,Marc R. Mansour,Marc R. Mansour,Keith Joung,A. Thomas Look +12 more
TL;DR: It is shown that homozygous loss of asxl1 in zebrafish leads to apoptosis of newly formed HSCs by upregulation of bim and bid, which supports the use of as xl1+/− zebra fish as a strategy to identify small-molecule drugs to suppress the growth of asXl1 mutant but not wild-type HSCS in individuals with somatically acquired inactivating mutations of ASXL1.
Posted ContentDOI
The experimental design and data interpretation in “Unexpected mutations after CRISPR–Cas9 editing in vivo” by Schaefer et al. are insufficient to support the conclusions drawn by the authors
Wilson Cj,Timothy Fennell,Anne Bothmer,Morgan L. Maeder,Deepak Reyon,Cecilia Cotta-Ramusino,Fernandez Ca,Eugenio Marco,Luis A. Barrera,Jayaram H,Albright Cf,Cox Gf,George M. Church,Vic E. Myer +13 more
TL;DR: It is believed that the conclusions drawn from this study are unsubstantiated by the disclosed experiments as they were designed and carried out and it is impossible to ascribe the observed differences in the subject mice to the effects of CRISPR per se.
Journal ArticleDOI
Zebrafish dscaml1 deficiency impairs retinal patterning and oculomotor function
Manxiu Ma,Manxiu Ma,Alexandro D. Ramirez,Tong Wang,Rachel L. Roberts,Katherine E. Harmon,David Schoppik,Avirale Sharma,Christopher Kuang,Stephanie Goei,James A. Gagnon,Steven Zimmerman,Shengdar Q. Tsai,Deepak Reyon,J. Keith Joung,Emre Aksay,Alexander F. Schier,Alexander F. Schier,Y. Albert Pan +18 more
TL;DR: Using the zebrafish model, this study shows that dscaml1 mutants have a host of oculomotor deficits, including severe fatigue during gaze stabilization, reduced saccade amplitude and velocity in the light, greater disconjugacy, and impaired fixation.
Journal ArticleDOI
Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.
Steven J. Grzegorski,Zhilian Hu,Zhilian Hu,Yang Liu,Xinge Yu,Allison C. Ferguson,Hasam Madarati,Alexander P. Friedmann,Deepak Reyon,Paul Y. Kim,Colin A. Kretz,J. Keith Joung,Jordan A. Shavit +12 more
TL;DR: The conserved function of thrombin in zebrafish is demonstrated and insight into the role of kringle 1 in prothrombin maturation and activity is provided to provide important insight into its pleiotropic functions as well as the management of patients with bleeding disorders.
Journal ArticleDOI
Identification of promoter targets of enhancers by epigenetic knockdown using TAL DNA binding proteins
Eric M. Mendenhall,Eric M. Mendenhall,Kaylyn E. Williamson,Kaylyn E. Williamson,Deepak Reyon,J. Keith Joung,Bradley E. Bernstein,Bradley E. Bernstein +7 more
TL;DR: A fundamental question in biology is how an organism’s genome controls cellular differentiation and identity to produce numerous distinct cell types, and this work designed TALs to target over 50 putative distal enhancers to relatively quantitate the contribution on transcriptional activation of the target enhancer.