E
Eric M. Mendenhall
Researcher at University of Alabama in Huntsville
Publications - 37
Citations - 8505
Eric M. Mendenhall is an academic researcher from University of Alabama in Huntsville. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 19, co-authored 32 publications receiving 7282 citations. Previous affiliations of Eric M. Mendenhall include Massachusetts Institute of Technology & Howard Hughes Medical Institute.
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Journal ArticleDOI
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Tarjei S. Mikkelsen,Manching Ku,Manching Ku,David B. Jaffe,Biju Issac,Biju Issac,Erez Lieberman Aiden,Erez Lieberman Aiden,Georgia Giannoukos,Pablo Alvarez,William Brockman,Tae Kyung Kim,Richard Koche,Richard Koche,Richard Koche,William Lee,Eric M. Mendenhall,Eric M. Mendenhall,Aisling O'Donovan,Aviva Presser,Carsten Russ,Xiaohui Xie,Alexander Meissner,Marius Wernig,Rudolf Jaenisch,Chad Nusbaum,Eric S. Lander,Eric S. Lander,Bradley E. Bernstein,Bradley E. Bernstein +29 more
TL;DR: The application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells is reported and it is shown that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms.
Journal ArticleDOI
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
Manching Ku,Richard Koche,Richard Koche,Richard Koche,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Eric M. Mendenhall,Eric M. Mendenhall,Mitsuhiro Endoh,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Aviva Presser,Aviva Presser,Chad Nusbaum,Xiaohui Xie,Andrew S. Chi,Andrew S. Chi,Mazhar Adli,Mazhar Adli,Simon Kasif,Leon M. Ptaszek,Chad A. Cowan,Eric S. Lander,Eric S. Lander,Haruhiko Koseki,Bradley E. Bernstein +26 more
TL;DR: It is proposed that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells.
Journal ArticleDOI
Expanded encyclopaedias of DNA elements in the human and mouse genomes
Jill Moore,Michael J. Purcaro,Henry Pratt,Charles B. Epstein,Noam Shoresh,Jessika Adrian,Trupti Kawli,Carrie A. Davis,Alexander Dobin,Rajinder Kaul,Jessica Halow,Eric L. Van Nostrand,Peter Freese,David U. Gorkin,David U. Gorkin,Yin Shen,Yin Shen,Yupeng He,Mark Mackiewicz,Florencia Pauli-Behn,Brian A. Williams,Ali Mortazavi,Cheryl A. Keller,Xiao-Ou Zhang,Shaimae I. Elhajjajy,Jack Huey,Diane E. Dickel,Valentina Snetkova,Xintao Wei,Xiaofeng Wang,Xiaofeng Wang,Juan Carlos Rivera-Mulia,Juan Carlos Rivera-Mulia,Joel Rozowsky,Jing Zhang,Surya B. Chhetri,Jialing Zhang,Alec Victorsen,Kevin P. White,Axel Visel,Axel Visel,Gene W. Yeo,Christopher B. Burge,Eric Lécuyer,Eric Lécuyer,David M. Gilbert,Job Dekker,John L. Rinn,Eric M. Mendenhall,Joseph R. Ecker,Manolis Kellis,Manolis Kellis,Robert J. Klein,William Stafford Noble,Anshul Kundaje,Roderic Guigó,Peggy J. Farnham,J. Michael Cherry,Richard M. Myers,Bing Ren,Bing Ren,Brenton R. Graveley,Mark Gerstein,Len A. Pennacchio,Len A. Pennacchio,Michael Snyder,Bradley E. Bernstein,Barbara J. Wold,Ross C. Hardison,Thomas R. Gingeras,John A. Stamatoyannopoulos,Zhiping Weng,Zhiping Weng,Zhiping Weng +73 more
TL;DR: The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development.
Journal ArticleDOI
GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells
Eric M. Mendenhall,Richard Koche,Thanh Truong,Thanh Truong,Thanh Truong,Vicky Weijie Zhou,Biju Issac,Biju Issac,Biju Issac,Andrew S. Chi,Manching Ku,Manching Ku,Manching Ku,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +15 more
TL;DR: In this paper, a series of engineered bacterial artificial chromosomes were integrated into embryonic stem (ES) cells and examined their chromatin, and it was shown that a 44 kb region corresponding to the Zfpm2 locus initiates de novo recruitment of PRC2.
Journal ArticleDOI
Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions
Eric M. Mendenhall,Kaylyn E. Williamson,Deepak Reyon,James Zou,Oren Ram,J. Keith Joung,Bradley E. Bernstein +6 more
TL;DR: It is found that inactivation of enhancer chromatin by TAL effector repeat domains fused to the LSD1 histone demethylase frequently causes downregulation of proximal genes, revealing enhancer target genes.