D
Delai Chen
Researcher at Massachusetts Institute of Technology
Publications - 41
Citations - 6042
Delai Chen is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: In vivo & Microchannel. The author has an hindex of 26, co-authored 41 publications receiving 5445 citations. Previous affiliations of Delai Chen include Harvard University & University of Illinois at Chicago.
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Patent
Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
TL;DR: In this paper, a method for sampling and/or introducing a matter to an environment comprises introducing a first array of plugs through a first microchannel of a device into an exchange region of the device in which mass transport between the environment and the plug fluid of at least one plug in the first array, and a second array of plug is formed.
Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery
Yunlong Zhang,Jeisa M. Pelet,Jeisa M. Pelet,Daniel A. Heller,Daniel A. Heller,Yizhou Dong,Delai Chen,Zhen Gu,Zhen Gu,Brian Joseph,Brian Joseph,Jasmine Wallas,Daniel G. Anderson +12 more
TL;DR: Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo.
Patent
Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
Minglin Ma,Daniel G. Anderson,Robert Langer,Omid Veiseh,Arturo J. Vegas,Joshua C. Doloff,Delai Chen,Christian J. Kastrup +7 more
TL;DR: In this article, a biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject.
Patent
Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof
Yizhou Dong,Kevin Love,Robert S. Langer,Daniel Griffith Anderson,Delai Chen,Yi Chen,Arturo J. Vegas,Akinleye Alabi,Yunlong Zhang +8 more
TL;DR: In this paper, the authors defined APPLs as compounds and compositions characterized by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, or structural isomer thereof.
Patent
1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
Yizhou Dong,Akinleye Alabi,Hao Yin,Joseph R. Dorkin,Delai Chen,Robert Langer,Daniel G. Anderson,Ahmed A. Eltoukhy +7 more
TL;DR: In this article, a 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds were provided.