B
Brian Joseph
Researcher at Kettering University
Publications - 15
Citations - 1251
Brian Joseph is an academic researcher from Kettering University. The author has contributed to research in topics: RNA splicing & Intron. The author has an hindex of 8, co-authored 15 publications receiving 947 citations. Previous affiliations of Brian Joseph include Massachusetts Institute of Technology & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation
Jakub Orzechowski Westholm,Pedro Miura,Pedro Miura,Sara Olson,Sol Shenker,Sol Shenker,Brian Joseph,Piero Sanfilippo,Susan E. Celniker,Brenton R. Graveley,Eric C. Lai +10 more
TL;DR: This work exploits massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >100 libraries covering diverse developmental stages, tissues, and cultured cells, to rigorously annotate >2,500 fruit fly circular RNAs, which exhibit commonalities and distinctions from mammalian circles.
Journal ArticleDOI
The m 6 A pathway facilitates sex determination in Drosophila
Lijuan Kan,Anya V. Grozhik,Jeffrey P. Vedanayagam,Deepak P. Patil,Nan Pang,Kok-Seong Lim,Yi-Chun Huang,Brian Joseph,Ching-Jung Lin,Vladimir Despic,Jian Guo,Dong Yan,Shu Kondo,Wu-Min Deng,Peter C. Dedon,Samie R. Jaffrey,Eric C. Lai +16 more
TL;DR: The transcriptomic and genetic toolkit reveals in vivo biologic function for the Drosophila m6A pathway, since miCLIP data reveal Sxl as a major intronic m521-B target, and female-specific SxL splicing is compromised in multiple m 6A pathway mutants.
Journal ArticleDOI
Remotely-activated protein-producing nanoparticles
Avi Schroeder,Michael S. Goldberg,Christian J. Kastrup,Yingxia Wang,Shan Jiang,Brian Joseph,Christopher G. Levins,Sneha T. Kannan,Robert Langer,Daniel G. Anderson +9 more
TL;DR: In this article, the authors developed nanoparticles that can be controllably triggered to synthesize proteins, including amino acids, ribosomes, and DNA caged with a photolabile protecting group.
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Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery.
Yunlong Zhang,Jeisa M. Pelet,Jeisa M. Pelet,Daniel A. Heller,Daniel A. Heller,Yizhou Dong,Delai Chen,Zhen Gu,Zhen Gu,Brian Joseph,Brian Joseph,Jasmine Wallas,Daniel G. Anderson +12 more
TL;DR: In this paper, lipid modified aminoglycosides are used to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo.
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A neural m 6 A/Ythdf pathway is required for learning and memory in Drosophila
Lijuan Kan,Stanislav Ott,Brian Joseph,Brian Joseph,Eun Sil Park,Wei Dai,Ralph E. Kleiner,Adam Claridge-Chang,Adam Claridge-Chang,Eric C. Lai +9 more
TL;DR: In this article, the authors used Drosophila melanogaster to study N6-methyladenosine (m6A), the most abundant modification of mRNA, and showed that m6A/Ythdf operate specifically via the mushroom body, the center for associative learning.