D
Delphine Fradin
Researcher at University of Nantes
Publications - 42
Citations - 1254
Delphine Fradin is an academic researcher from University of Nantes. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 16, co-authored 37 publications receiving 1038 citations. Previous affiliations of Delphine Fradin include French Institute of Health and Medical Research & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index
Andrew P. Feinberg,Andrew P. Feinberg,Rafael A. Irizarry,Delphine Fradin,Delphine Fradin,Martin J. Aryee,Peter Murakami,Peter Murakami,Thor Aspelund,Gudny Eiriksdottir,Tamara B. Harris,Lenore J. Launer,Vilmundur Gudnason,M. Daniele Fallin +13 more
TL;DR: A genome-scale, gene-specific analysis of DNA methylation in the same individuals over a decade apart identifies a personalized epigenomic signature that may correlate with a common genetic trait.
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XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes.
TL;DR: It is demonstrated that XPG endonuclease promotes DNA breaks and DNA demethylation at promoters allowing the recruitment of CTCF and gene looping, which is further stabilized by XPF.
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Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes
Delphine Fradin,Sophie Le Fur,Clémence Mille,Nadia Naoui,C J Groves,Diana Zelenika,Mark I. McCarthy,Mark Lathrop,Pierre Bougnères +8 more
TL;DR: The observation of a CpG-specific, locus-specific methylation pattern, although it can provide an epigenetic biomarker of a multifactorial disease, does not indicate whether the reported epigenetic pattern preexists or follows the establishment of T1D.
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MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Virginie Vignard,Maureen Labbé,Nadège Marec,Gwennan André-Grégoire,Nicolas Jouand,Jean-François Fonteneau,Nathalie Labarrière,Delphine Fradin +7 more
TL;DR: It is demonstrated that CD8+ T cells internalize exosomes from different tumor types even if these cells do not internalize vesicles as readily as other immune cells, and suggested that miRNAs in melanoma-derived exosome aid tumor immune evasion and could be a therapeutic target.
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Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs
Delphine Fradin,Delphine Fradin,Keely Cheslack-Postava,Christine Ladd-Acosta,Craig J. Newschaffer,Aravinda Chakravarti,Dan E. Arking,Andrew P. Feinberg,M. Daniele Fallin +8 more
TL;DR: These regions may harbor imprinted sites associated with the development of autism and offer fruitful domains for molecular investigation into the role of epigenetic mechanisms in autism.