G
Gwennan André-Grégoire
Researcher at University of Nantes
Publications - 21
Citations - 428
Gwennan André-Grégoire is an academic researcher from University of Nantes. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 9, co-authored 15 publications receiving 236 citations. Previous affiliations of Gwennan André-Grégoire include French Institute of Health and Medical Research.
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Journal ArticleDOI
MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Virginie Vignard,Maureen Labbé,Nadège Marec,Gwennan André-Grégoire,Nicolas Jouand,Jean-François Fonteneau,Nathalie Labarrière,Delphine Fradin +7 more
TL;DR: It is demonstrated that CD8+ T cells internalize exosomes from different tumor types even if these cells do not internalize vesicles as readily as other immune cells, and suggested that miRNAs in melanoma-derived exosome aid tumor immune evasion and could be a therapeutic target.
Journal ArticleDOI
Pharmacological targeting of apelin impairs glioblastoma growth.
Elizabeth Harford-Wright,Elizabeth Harford-Wright,Gwennan André-Grégoire,Kathryn A Jacobs,Lucas Treps,Sophie Le Gonidec,Héloïse M. Leclair,Héloïse M. Leclair,Sara Gonzalez-Diest,Sara Gonzalez-Diest,Quentin Roux,François Guillonneau,Delphine Loussouarn,Lisa Oliver,François M. Vallette,Fabienne Foufelle,Philippe Valet,Anthony P. Davenport,Robert C. Glen,Robert C. Glen,Nicolas Bidère,Nicolas Bidère,Julie Gavard,Julie Gavard +23 more
TL;DR: It is shown that the vasoactive peptide apelin, secreted by brain endothelial cells, regulates glioblastoma patient-derived cells with stem-like properties and pharmacological blockade of apelin hampers gliOBlastoma cell expansion and improves survival in xenografted mice.
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Temozolomide affects Extracellular Vesicles Released by Glioblastoma Cells
TL;DR: While relatively inefficient in killing GSCs in vitro, temozolomide could instead increase the release of pro-tumoral information, as well as ribosome- and proteasome-associated networks.
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Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.
Shima Ghoroghi,Shima Ghoroghi,Benjamin Mary,Benjamin Mary,Annabel Larnicol,Annabel Larnicol,Nandini Asokan,Nandini Asokan,Annick Klein,Annick Klein,Naël Osmani,Naël Osmani,Ignacio Busnelli,Ignacio Busnelli,François Delalande,Nicodème Paul,Nicodème Paul,Sébastien Halary,Frédéric Gros,Frédéric Gros,Laetitia Fouillen,Anne-Marie Haeberlé,Catherine A. Royer,Coralie Spiegelhalter,Gwennan André-Grégoire,Vincent Mittelheisser,Alexandre Detappe,Kendelle J. Murphy,Kendelle J. Murphy,Paul Timpson,Paul Timpson,Raphael Carapito,Raphael Carapito,Marcel Blot-Chabaud,Julie Gavard,Christine Carapito,Nicolas Vitale,Olivier Lefebvre,Olivier Lefebvre,Jacky G. Goetz,Jacky G. Goetz,Vincent Hyenne +41 more
TL;DR: In this paper, the authors show that GTPases of the Ral family control multi-vesicular bodies homeostasis and tune the biogenesis and secretion of pro-metastatic EVs.
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CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.
TL;DR: CYLD marshals the centriolar satellites by deubiquitinating and preventing the E3 ligase Mindbomb 1 (MIB1) from marking PCM1 for proteasomal degradation and providing insight into how reversible ubiquitination finely tunes ciliogenesis.