Denis Smirnov

TL;DR: A specific marker of human PMN-MDSC associated with ER stress and lipid metabolism is identified, which provides new insights into the biology and potential therapeutic targeting of these cells.

TL;DR: A novel approach for the identification of molecular markers to detect and characterize CTCs in peripheral blood and it is shown that gene expression profiles for C TCs may be used to distinguish normal donors from advanced cancer patients as well as to differentiate among the three different metastatic cancers.

TL;DR: This review focuses on various microfluidic approaches that have been applied to date to capture CTCs from the blood of patients with cancer.

TL;DR: Isolating and characterizing CTCs from patients with metastatic CRC is feasible, change in the CTC number might reflect clinical status, and flow cytometric and gene expression data suggest similarity of circulating and in situ tumor cells.

TL;DR: In this article, a list of 61 marker genes for CEC detection was generated, and their expression was measured by real-time quantitative PCR in blood samples from 81 metastatic cancer patients and 55 healthy donors that were immunomagnetically enriched for the CECs.