Evgenii N. Tcyganov

TL;DR: Current understanding is discussed as to the nature of differences in the function and fate of MDSC in the tumor and peripheral lymphoid organs, the underlying mechanisms, and their potential impact on the regulation of tumor progression.

TL;DR: A specific marker of human PMN-MDSC associated with ER stress and lipid metabolism is identified, which provides new insights into the biology and potential therapeutic targeting of these cells.

TL;DR: In this paper, the authors discuss the differences in the function and fate of myeloid-derived suppressor cells (MDSC) in the tumor and peripheral lymphoid organs and discuss the current understanding as to the nature of these differences, the underlying mechanisms and their potential impact on the regulation of tumor progression.

TL;DR: This work has shown that differentiation of M-MDSC to macrophages and dendritic cells is shaped by tumor microenvironment, and the mechanisms of this process start to emerge.

TL;DR: In this paper, the heterogeneity of polymorphonuclear neutrophils (PMNs) in cancer was characterized using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis.