Brian Nam

TL;DR: A specific marker of human PMN-MDSC associated with ER stress and lipid metabolism is identified, which provides new insights into the biology and potential therapeutic targeting of these cells.

TL;DR: It is demonstrated that carcinoma-associated fibroblasts (CAF) are major sources of chemokines that recruit granulocytes to tumors, and CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.

TL;DR: It is reported that mouse and human PMN-MDSCs exclusively upregulate fatty acid transport protein 2 (FATP2), and FATP2 mediates the acquisition of immunosuppressive activity by PMn-M DSCs and represents a target to inhibit the functions of PMN, MDSCs selectively and to improve the efficiency of cancer therapy.

TL;DR: It is demonstrated that neutrophils have tumor-stage-dependent alterations in motility, function and metabolism: in early phases, they are highly motile with altered metabolism, whereas at later stages, they become highly suppressive.

TL;DR: In this paper, the heterogeneity of polymorphonuclear neutrophils (PMNs) in cancer was characterized using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis.