K
Kevin Alicea-Torres
Researcher at Wistar Institute
Publications - 10
Citations - 954
Kevin Alicea-Torres is an academic researcher from Wistar Institute. The author has contributed to research in topics: Tumor progression & Myeloid-derived Suppressor Cell. The author has an hindex of 6, co-authored 7 publications receiving 572 citations.
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Journal ArticleDOI
Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
Thomas Condamine,George A. Dominguez,Je-In Youn,Andrew V. Kossenkov,Sridevi Mony,Kevin Alicea-Torres,Evgenii N. Tcyganov,Ayumi Hashimoto,Yulia Nefedova,Cindy Lin,Simona Partlova,Alfred L. Garfall,Dan T. Vogl,Xiaowei Xu,Stella C. Knight,George Malietzis,Gui Han Lee,Evgeniy Eruslanov,Steven M. Albelda,Xianwei Wang,Jawahar L. Mehta,Meenakshi Bewtra,Anil K. Rustgi,Neil Hockstein,Robert L Witt,Gregory A. Masters,Brian Nam,Denis Smirnov,Manuel A. Sepulveda,Dmitry I. Gabrilovich +29 more
TL;DR: A specific marker of human PMN-MDSC associated with ER stress and lipid metabolism is identified, which provides new insights into the biology and potential therapeutic targeting of these cells.
Journal ArticleDOI
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
Filippo Veglia,Vladimir A. Tyurin,Dariush Mohammadyani,Dariush Mohammadyani,Maria Blasi,Elizabeth K. Duperret,Laxminarasimha Donthireddy,Ayumi Hashimoto,Alexandr A. Kapralov,Andrew A. Amoscato,Roberto Angelini,Sima Patel,Kevin Alicea-Torres,David B. Weiner,Maureen E. Murphy,Judith Klein-Seetharaman,Esteban Celis,Valerian E. Kagan,Dmitry I. Gabrilovich +18 more
TL;DR: It is found that impaired cross-presentation in DCs is largely associated with defect in trafficking of peptide–MHC class I (pMHC) complexes to the cell surface, caused by the interaction of electrophilic lipids with chaperone heat shock protein 70.
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Unique pattern of neutrophil migration and function during tumor progression.
Sima R. Patel,Sima R. Patel,Shuyu Fu,Shuyu Fu,Jérôme Mastio,George A. Dominguez,Abhilasha Purohit,Andrew V. Kossenkov,Cindy Lin,Kevin Alicea-Torres,Mohit Sehgal,Yulia Nefedova,Jie Zhou,Lucia R. Languino,Cynthia Clendenin,Robert H. Vonderheide,Charles Mulligan,Brian Nam,Neil Hockstein,Gregory A. Masters,Michael J. Guarino,Zachary T. Schug,Dario C. Altieri,Dmitry I. Gabrilovich +23 more
TL;DR: It is demonstrated that neutrophils have tumor-stage-dependent alterations in motility, function and metabolism: in early phases, they are highly motile with altered metabolism, whereas at later stages, they become highly suppressive.
Journal ArticleDOI
ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer
Sushil Kumar,David W. Wilkes,Nina Samuel,Mario Andres Blanco,Anupma Nayak,Kevin Alicea-Torres,Christian Gluck,Satrajit Sinha,Dmitry I. Gabrilovich,Rumela Chakrabarti +9 more
TL;DR: Findings identify a unique crosstalk between &Dgr;Np63+ TNBC cells and MDSCs that promotes tumor progression and metastasis, which could be exploited in future combined immunotherapy/chemotherapy strategies for TNBC patients.
Journal ArticleDOI
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway
Kevin Alicea-Torres,Emilio Sanseviero,Emilio Sanseviero,Jun Gui,Jinyun Chen,Filippo Veglia,Qiujin Yu,Laxminarasimha Donthireddy,Andrew V. Kossenkov,Cindy Lin,Shuyu Fu,Charles Mulligan,Brian Nam,Gregory A. Masters,Fred Denstman,Joseph R. Bennett,Neil Hockstein,Agnieszka Rynda-Apple,Yulia Nefedova,Serge Y. Fuchs,Dmitry I. Gabrilovich +20 more
TL;DR: In this paper, the authors present evidence that type I interferons (IFN1) receptor signaling serves as a universal mechanism that restricts acquisition of suppressive activity by myeloid-derived suppressor cells.