D
Dennis C. Dean
Researcher at Merck & Co.
Publications - 76
Citations - 5370
Dennis C. Dean is an academic researcher from Merck & Co.. The author has contributed to research in topics: Radioligand & Receptor. The author has an hindex of 27, co-authored 76 publications receiving 5169 citations. Previous affiliations of Dennis C. Dean include United States Military Academy.
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Journal ArticleDOI
Validation of (-)-n-3-benzyl-phenobarbital as a selective inhibitor of cyp2c19 in human liver microsomes
Xiaoxin Cai,Regina W. Wang,Richard W. Edom,David C. Evans,Magang Shou,A. David Rodrigues,Wensheng Liu,Dennis C. Dean,Thomas A. Baillie +8 more
TL;DR: NBPB can be used as a potent and selective inhibitor to establish the relative contribution of CYP2C19 for in vitro reaction phenotyping studies and can also serve as a positive control inhibitor of CY P450 reversible inhibition when human liver microsomes are used as the enzyme source.
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1,3-Dipole cascade. A new method for azomethine ylide formation
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Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand
Scott E. Wolkenberg,Zhijian Zhao,Marianna Kapitskaya,Andrea L. Webber,Konstantin Petrukhin,Yui Sing Tang,Dennis C. Dean,George D. Hartman,Craig W. Lindsley +8 more
TL;DR: Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM and a tritiated analogue of one agonist was prepared to aid in the development of a binding assay.
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A convenient method for [14C] carbonylation reactions
TL;DR: In this article, a simple method for generation of 14CO from Ba14CO3 has been developed, which was shown to proceed in good yield with a variety of substrates.
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Synthesis of the first sulfur-35-labeled hERG radioligand.
Conrad E. Raab,John W. Butcher,Thomas M. Connolly,Jerzy Karczewski,Nathan X. Yu,Steven J. Staskiewicz,Nigel J. Liverton,Dennis C. Dean,David G. Melillo +8 more
TL;DR: The synthesis of the first high specific activity S-35-labeled hERG radioligand, [(35)S]MK-0499, for use in HTS assays of drug candidates for hERG interaction is described.