D
Dennis C. Dean
Researcher at Merck & Co.
Publications - 76
Citations - 5370
Dennis C. Dean is an academic researcher from Merck & Co.. The author has contributed to research in topics: Radioligand & Receptor. The author has an hindex of 27, co-authored 76 publications receiving 5169 citations. Previous affiliations of Dennis C. Dean include United States Military Academy.
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Journal ArticleDOI
Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin by Human Organic Anion Transporter 3, Organic Anion Transporting Polypeptide 4C1, and Multidrug Resistance P-glycoprotein
Xiaoyan Chu,Kelly Bleasby,Jocelyn Yabut,Xiaoxin Cai,Grace Chan,Michael J. Hafey,Shiyao Xu,Arthur J. Bergman,Matthew P. Braun,Dennis C. Dean,Raymond Evers +10 more
TL;DR: The data indicate that sitagliptin is unlikely to be a perpetrator of drug-drug interactions with Pgp, hOAT1, or hOat3 substrates at clinically relevant concentrations, and the effects may not be clinically meaningful, due to the high safety margin of sitgliptin.
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Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats.
William H. Schaefer,Jeffery W Lawrence,Amy F Loughlin,Dana A. Stoffregen,Lori Mixson,Dennis C. Dean,Conrad E. Raab,Nathan X. Yu,George R. Lankas,Clay B. Frederick +9 more
TL;DR: It is suggested that neither mitochondrial injury, nor a decrease in muscle ubiquinone levels, is the primary cause of skeletal myopathy in cerivastatin-dosed rats.
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Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues
Scott D. Feighner,Andrew D. Howard,Kristine Prendergast,Oksana C. Palyha,Donna L. Hreniuk,Ravi P. Nargund,Dennis J. Underwood,James R. Tata,Dennis C. Dean,Carina P. Tan,Karen K. McKee,John Woods,Arthur A. Patchett,Roy G. Smith,Lex H.T. Van der Ploeg +14 more
TL;DR: Antibodies raised against an intracellular and extracellular domain of the GH secretagogue receptor (GHS-R) confirmed that its topological orientation in the lipid bilayer is as predicted for G protein-coupled receptors with seven transmembrane domains.
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Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
Steven W. Ludmerer,Vivien A. Warren,Brande S. Williams,Yingcong Zheng,David C. Hunt,Michelle B. Ayer,Michael A. Wallace,Ashok Chaudhary,Marjorie A. Egan,Peter T. Meinke,Dennis C. Dean,Maria L. Garcia,Doris F. Cully,McHardy M. Smith +13 more
TL;DR: This co-association of DmGluCl alpha and DmRdl represents the first biochemical and immunological evidence of coassembly of subunits from two different subclasses of ligand-gated ion channel subunits.
Journal Article
Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.
S K Balani,Xin Xu,Byron H. Arison,Maria V. Silva,A. M Y Gries,Florencia A. deLuna,Donghui Cui,P H Kari,Trung Ly,Cornelis E. C. A. Hop,Rominder Singh,Michael A. Wallace,Dennis C. Dean,Jiunn H. Lin,Paul G. Pearson,Thomas A. Baillie +15 more
TL;DR: Caspofungin acetate is a semisynthetic pneumocandin derivative being developed as a parenteral antifungal agent with broad-spectrum activity against systemic infections such as those caused by Candida and Aspergillus species.